1-Acetyl-β-carboline (Synonyms: 1-(9H-pyrido[3,4-b]indol-1-yl)ethanone)

Cat. No.: HY-W060074 Purity: 97.04%: FAQs
Data Sheet SDS COA Handling Instructions Technical Support

1-Acetyl-β-carboline is metabolite of Nonomuraea endophytica.

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1-Acetyl-β-carboline Chemical Structure

Size	Stock	Quantity
1 mg	In-stock	Estimated Time of Arrival: December 31
5 mg	In-stock	Estimated Time of Arrival: December 31
10 mg	Get quote
50 mg	Get quote

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Description

1-Acetyl-β-carboline is metabolite of Nonomuraea endophytica^[1].

Cellular Effect

Cell Line	Type	Value	Description	References
A549	GI₅₀	> 40 μM Compound: 41	Cytotoxicity activity against human A549 cells assessed as growth inhibition at 10 ug/ml after 72 hrs sulforhodamine B assay Cytotoxicity activity against human A549 cells assessed as growth inhibition at 10 ug/ml after 72 hrs sulforhodamine B assay	[PMID: 21316977]
A549	IC₅₀	> 50 μM Compound: 7	Cytotoxicity against human A549 cells after 48 hrs by MTT assay Cytotoxicity against human A549 cells after 48 hrs by MTT assay	[PMID: 21977916]
DU-145	GI₅₀	> 40 μM Compound: 41	Cytotoxicity activity against human DU145 cells assessed as growth inhibition at 10 ug/ml after 72 hrs sulforhodamine B assay Cytotoxicity activity against human DU145 cells assessed as growth inhibition at 10 ug/ml after 72 hrs sulforhodamine B assay	[PMID: 21316977]
DU-145	IC₅₀	> 50 μM Compound: 7	Cytotoxicity against human DU145 cells after 48 hrs by MTT assay Cytotoxicity against human DU145 cells after 48 hrs by MTT assay	[PMID: 21977916]
HeLa	IC₅₀	> 50 μM Compound: 7	Cytotoxicity against human HeLa cells after 48 hrs by MTT assay Cytotoxicity against human HeLa cells after 48 hrs by MTT assay	[PMID: 21977916]
HT-22	IC₅₀	> 100 μM Compound: 31	Cytotoxicity against mouse HT-22 cells assessed as reduction in cell viability incubated for 48 hrs by MTS assay Cytotoxicity against mouse HT-22 cells assessed as reduction in cell viability incubated for 48 hrs by MTS assay	[PMID: 36876904]
KB	GI₅₀	> 40 μM Compound: 41	Cytotoxicity activity against human KB cells assessed as growth inhibition at 10 ug/ml after 72 hrs sulforhodamine B assay Cytotoxicity activity against human KB cells assessed as growth inhibition at 10 ug/ml after 72 hrs sulforhodamine B assay	[PMID: 21316977]
MCF7	IC₅₀	> 50 μM Compound: 7	Cytotoxicity against human MCF7 cells after 48 hrs by MTT assay Cytotoxicity against human MCF7 cells after 48 hrs by MTT assay	[PMID: 21977916]
MDA-MB-231	IC₅₀	> 50 μM Compound: 7	Cytotoxicity against human MDA-MB-231 cells after 48 hrs by MTT assay Cytotoxicity against human MDA-MB-231 cells after 48 hrs by MTT assay	[PMID: 21977916]
NCI-H460	IC₅₀	> 50 μM Compound: 7	Cytotoxicity against human NCI-H460 cells after 48 hrs by MTT assay Cytotoxicity against human NCI-H460 cells after 48 hrs by MTT assay	[PMID: 21977916]
Neutrophil	IC₅₀	5.03 μM Compound: 41	Antiinflammatory activity against human neutrophil assessed as inhibition of N-formyl-l-methionyl phenylalanine/cytochalasin B-induced superoxide anion generation by spectrophotometry Antiinflammatory activity against human neutrophil assessed as inhibition of N-formyl-l-methionyl phenylalanine/cytochalasin B-induced superoxide anion generation by spectrophotometry	[PMID: 21316977]
SMMC-7721	IC₅₀	> 50 μM Compound: 7	Cytotoxicity against human SMMC7721 cells after 48 hrs by MTT assay Cytotoxicity against human SMMC7721 cells after 48 hrs by MTT assay	[PMID: 21977916]
SW1990	IC₅₀	> 50 μM Compound: 7	Cytotoxicity against human SW1990 cells after 48 hrs by MTT assay Cytotoxicity against human SW1990 cells after 48 hrs by MTT assay	[PMID: 21977916]

Molecular Weight

210.23

Formula

C₁₃H₁₀N₂O

CAS No.

50892-83-6

Appearance

Solid

Color

Light yellow to yellow

SMILES

CC(C1=NC=CC2=C1NC3=CC=CC=C32)=O

Structure Classification

Initial Source

Microorganisms

Nonomuraea endophytica

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Powder	-20°C	3 years
	4°C	2 years
In solvent	-80°C	6 months
	-20°C	1 month

Solvent & Solubility

In Vitro:

DMSO : 50 mg/mL (237.83 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	4.7567 mL	23.7835 mL	47.5670 mL
5 mM	0.9513 mL	4.7567 mL	9.5134 mL
10 mM	0.4757 mL	2.3783 mL	4.7567 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Molarity Calculator
Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Concentration _(start)

Volume _(start)

Concentration _(final)

Volume _(final)

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

Dosage

mg/kg

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(per animal)

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(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Calculation results:

Working solution concentration: mg/mL

Purity & Documentation

Purity: 97.04%

Select Batch:

Data Sheet (273 KB) SDS (393 KB)

COA (255 KB) HNMR (245 KB) RP-HPLC (208 KB) MS (69 KB)

Handling Instructions (2659 KB)

References

[1]. PROKSA B, et al. 1-Acetyl-β-carboline, a new metabolite of Streptomyces kasugaensis. Acta Biotechnologica (Acta Biotechnol). Volume： 10 Issue： 4 Page： 337-340 Publication year： 1990.

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

DMSO	1 mM	4.7567 mL	23.7835 mL	47.5670 mL	118.9174 mL
	5 mM	0.9513 mL	4.7567 mL	9.5134 mL	23.7835 mL
	10 mM	0.4757 mL	2.3783 mL	4.7567 mL	11.8917 mL
	15 mM	0.3171 mL	1.5856 mL	3.1711 mL	7.9278 mL
	20 mM	0.2378 mL	1.1892 mL	2.3783 mL	5.9459 mL
	25 mM	0.1903 mL	0.9513 mL	1.9027 mL	4.7567 mL
	30 mM	0.1586 mL	0.7928 mL	1.5856 mL	3.9639 mL
	40 mM	0.1189 mL	0.5946 mL	1.1892 mL	2.9729 mL
	50 mM	0.0951 mL	0.4757 mL	0.9513 mL	2.3783 mL
	60 mM	0.0793 mL	0.3964 mL	0.7928 mL	1.9820 mL
	80 mM	0.0595 mL	0.2973 mL	0.5946 mL	1.4865 mL
	100 mM	0.0476 mL	0.2378 mL	0.4757 mL	1.1892 mL

1-Acetyl-β-carboline Related Classifications

Infection

Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

1-Acetyl-β-carboline50892-83-61-(9H-pyrido[3,4-b]indol-1-yl)ethanoneOthersInhibitorinhibitorinhibit

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1-Acetyl-β-carboline (Synonyms: 1-(9H-pyrido[3,4-b]indol-1-yl)ethanone)

1-Acetyl-β-carboline Related Antibodies

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Biological Activity

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References

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Molarity Calculator

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