2. Metabolic Enzyme/Protease
  3. Lipoxygenase
  4. 1-Naphthyl 3,5-dinitrobenzoate

1-Naphthyl 3,5-dinitrobenzoate 

Cat. No.: HY-125975 Purity: 99.49%
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1-Naphthyl 3,5-dinitrobenzoate is a potent 5-lipoxygenase inhibitor with IC50 values of 1.04 µM and 3.6 µM for 5-LOX and mPGES-1, respectively. 1-Naphthyl 3,5-dinitrobenzoate has strong inhibition activity in the human whole blood (HWB) assay with an IC50 value of 8.6 μM. 1-Naphthyl 3,5-dinitrobenzoate can be used in research of inflammation.

For research use only. We do not sell to patients.

1-Naphthyl 3,5-dinitrobenzoate Chemical Structure

1-Naphthyl 3,5-dinitrobenzoate Chemical Structure

CAS No. : 93261-39-3

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Based on 1 publication(s) in Google Scholar

1-Naphthyl 3,5-dinitrobenzoate Related Antibodies

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5-LOX 12-LOX 15-LOX

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Description

1-Naphthyl 3,5-dinitrobenzoate is a potent 5-lipoxygenase inhibitor with IC50 values of 1.04 µM and 3.6 µM for 5-LOX and mPGES-1, respectively. 1-Naphthyl 3,5-dinitrobenzoate has strong inhibition activity in the human whole blood (HWB) assay with an IC50 value of 8.6 μM. 1-Naphthyl 3,5-dinitrobenzoate can be used in research of inflammation[1].

Molecular Weight

338.27

Formula

C17H10N2O6
CAS No.
Appearance

Solid

Color

Off-white to light yellow

SMILES

O=C(OC1=C2C=CC=CC2=CC=C1)C3=CC([N+]([O-])=O)=CC([N+]([O-])=O)=C3
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 10 mg/mL (29.56 mM; ultrasonic and warming and heat to 60°C; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.9562 mL 14.7811 mL 29.5622 mL
5 mM 0.5912 mL 2.9562 mL 5.9124 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

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C2

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V2

In Vivo Dissolution Calculator
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Calculation results:
Working solution concentration: mg/mL
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 2.9562 mL 14.7811 mL 29.5622 mL 73.9055 mL
5 mM 0.5912 mL 2.9562 mL 5.9124 mL 14.7811 mL
10 mM 0.2956 mL 1.4781 mL 2.9562 mL 7.3905 mL
15 mM 0.1971 mL 0.9854 mL 1.9708 mL 4.9270 mL
20 mM 0.1478 mL 0.7391 mL 1.4781 mL 3.6953 mL
25 mM 0.1182 mL 0.5912 mL 1.1825 mL 2.9562 mL
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1-Naphthyl 3,5-dinitrobenzoate Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

1-Naphthyl 3,5-dinitrobenzoate93261-39-3LipoxygenaseLOXmPGES-1bloodinflammationInhibitorinhibitorinhibit

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