2. Metabolic Enzyme/Protease Cell Cycle/DNA Damage Stem Cell/Wnt TGF-beta/Smad
  3. HSP TGF-beta/Smad
  4. 10,11-Dehydrocurvularin

10,11-Dehydrocurvularin is a prevalent fungal phytotoxin and an antibiotic. 10,11-Dehydrocurvularin is a strong activator of the heat shock response. 10,11-Dehydrocurvularin inhibits TGF-β signalling pathway. Anti-tumorous activity.

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10,11-Dehydrocurvularin Chemical Structure

10,11-Dehydrocurvularin Chemical Structure

CAS No. : 21178-57-4

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Based on 1 publication(s) in Google Scholar

Other Forms of 10,11-Dehydrocurvularin:

10,11-Dehydrocurvularin Related Antibodies

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Description

10,11-Dehydrocurvularin is a prevalent fungal phytotoxin and an antibiotic. 10,11-Dehydrocurvularin is a strong activator of the heat shock response. 10,11-Dehydrocurvularin inhibits TGF-β signalling pathway. Anti-tumorous activity[1][2].

Molecular Weight

290.31

Formula

C16H18O5
CAS No.
Appearance

Solid

Color

White to light yellow

SMILES

OC1=C(C(/C=C/CCC[C@@H]2C)=O)C(CC(O2)=O)=CC(O)=C1
Structure Classification
Initial Source

Aspergillus terreus
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : ≥ 30 mg/mL (103.34 mM; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

*"≥" means soluble, but saturation unknown.

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 3.4446 mL 17.2230 mL 34.4459 mL
5 mM 0.6889 mL 3.4446 mL 6.8892 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

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In Vivo Dissolution Calculator
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Calculation results:
Working solution concentration: mg/mL
Purity & Documentation

Purity: 99.75%

COA (253 KB) LCMS (94 KB)

Handling Instructions (2659 KB)
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 3.4446 mL 17.2230 mL 34.4459 mL 86.1148 mL
5 mM 0.6889 mL 3.4446 mL 6.8892 mL 17.2230 mL
10 mM 0.3445 mL 1.7223 mL 3.4446 mL 8.6115 mL
15 mM 0.2296 mL 1.1482 mL 2.2964 mL 5.7410 mL
20 mM 0.1722 mL 0.8611 mL 1.7223 mL 4.3057 mL
25 mM 0.1378 mL 0.6889 mL 1.3778 mL 3.4446 mL
30 mM 0.1148 mL 0.5741 mL 1.1482 mL 2.8705 mL
40 mM 0.0861 mL 0.4306 mL 0.8611 mL 2.1529 mL
50 mM 0.0689 mL 0.3445 mL 0.6889 mL 1.7223 mL
60 mM 0.0574 mL 0.2870 mL 0.5741 mL 1.4352 mL
80 mM 0.0431 mL 0.2153 mL 0.4306 mL 1.0764 mL
100 mM 0.0344 mL 0.1722 mL 0.3445 mL 0.8611 mL
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10,11-Dehydrocurvularin Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

10,11-Dehydrocurvularin21178-57-4HSPTGF-beta/SmadHeat shock proteinsTransforming growth factor betaInhibitorinhibitorinhibit

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