2. NF-κB
  3. NF-κB
  4. 11-Hydroxytephrosin

11-Hydroxytephrosin is a potent inhibitor of NF-kappaB. NF-kappaB is known to play a crucial role in the regulation of genes controlling the immune system, apoptosis, tumor cell growth, and tissue differentiation.

For research use only. We do not sell to patients.

11-Hydroxytephrosin Chemical Structure

11-Hydroxytephrosin Chemical Structure

CAS No. : 72458-85-6

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Based on 1 publication(s) in Google Scholar

11-Hydroxytephrosin Related Antibodies

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Description

11-Hydroxytephrosin is a potent inhibitor of NF-kappaB. NF-kappaB is known to play a crucial role in the regulation of genes controlling the immune system, apoptosis, tumor cell growth, and tissue differentiation[1].

Cellular Effect
Cell Line Type Value Description References
HeLa IC50
0.19 μM
Compound: 2
Inhibition of TNF-alpha-induced NF-kappaB activation in human HeLa cells by SEAP reporter gene assay
Inhibition of TNF-alpha-induced NF-kappaB activation in human HeLa cells by SEAP reporter gene assay
[PMID: 18841906]
RAW264.7 IC50
4.21 μM
Compound: 2
Inhibition of LPS-induced NF-kappaB activation in mouse RAW264.7 cells by SEAP reporter gene assay
Inhibition of LPS-induced NF-kappaB activation in mouse RAW264.7 cells by SEAP reporter gene assay
[PMID: 18841906]
Molecular Weight

426.42

Formula

C23H22O8
CAS No.
Appearance

Solid

Color

White to off-white

SMILES

O=C1[C@]2(O)[C@](COC3=CC(OC)=C(OC)C=C32)([H])OC4=C5C=CC(C)(C)OC5=CC(O)=C14
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

-20°C, protect from light

*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

Purity & Documentation

Purity: ≥98.0%

SDS (251 KB)

COA (253 KB)

Handling Instructions (2659 KB)
References
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11-Hydroxytephrosin Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

11-Hydroxytephrosin72458-85-6NF-κBNuclear factor-κBNuclear factor-kappaBNF-kappaBimmune systemapoptosistumor cell growthtissue differentiationInhibitorinhibitorinhibit

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