11-Ketodihydrotestosterone-d₃ (Synonyms: 11-KDHT-d₃; 5α-Dihydro-11-keto testosterone-d₃)

Cat. No.: HY-135794S Purity: 99.00%: FAQs
Data Sheet SDS COA Handling Instructions

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11-Ketodihydrotestosterone-d₃ is the deuterium labeled 11-Ketodihydrotestosterone. 11-Ketodihydrotestosterone (11-KDHT; 5α-Dihydro-11-keto testosterone) is an endogenous steroid and a metabolite of 11β-Hydroxyandrostenedione. 11-Ketodihydrotestosterone is an active androgen and is also a potent androgen receptor (AR) agonist with a Ki of 20.4 nM and an EC50 of 1.35 nM for human AR. 11-Ketodihydrotestosterone drives gene regulation, protein expression and cell growth in androgen-dependent prostate cancer cells[1][2].

For research use only. We do not sell to patients.

11-Ketodihydrotestosterone-d<sub>3</sub> Chemical Structure

11-Ketodihydrotestosterone-d₃ Chemical Structure

CAS No. : 2479914-02-6

Size	Price	Stock	Quantity
500 μg	USD 80	In-stock	Estimated Time of Arrival: December 31
1 mg	USD 130	In-stock	Estimated Time of Arrival: December 31
5 mg		Get quote
10 mg		Get quote

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Other Forms of 11-Ketodihydrotestosterone-d₃:

11-Ketodihydrotestosterone Get quote

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Description

In Vitro

Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

307.44

Formula

C₁₉H₂₅D₃O₃

CAS No.

2479914-02-6

Unlabeled CAS

32694-37-4

Appearance

Solid

Color

White to off-white

SMILES

O[C@]1(C([2H])(C[C@@]([H])([C@@]2(CC[C@]3(CC(CC[C@@]3([C@]24[H])C)=O)[H])[H])[C@@]1(CC4=O)C)[2H])[2H]

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Powder	-20°C	3 years
In solvent	-80°C	6 months
	-20°C	1 month

Solvent & Solubility

In Vitro:

DMSO : 100 mg/mL (325.27 mM; Need ultrasonic and warming; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	3.2527 mL	16.2633 mL	32.5267 mL
5 mM	0.6505 mL	3.2527 mL	6.5053 mL
10 mM	0.3253 mL	1.6263 mL	3.2527 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Concentration _(start)

Volume _(start)

Concentration _(final)

Volume _(final)

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

Dosage

mg/kg

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(per animal)

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(per animal)

μL

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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Calculation results:

Working solution concentration: mg/mL

Purity & Documentation

Purity: 99.00%

Select Batch:

Data Sheet (277 KB) SDS (252 KB)

COA (255 KB)

Handling Instructions (2659 KB)

References

[1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53(2):211-216. [Content Brief]

[2]. Pretorius E, et al. 1-Ketotestosterone and 11-Ketodihydrotestosterone in Castration Resistant Prostate Cancer: Potent Androgens Which Can No Longer Be Ignored. PLoS One. 2016 Jul 21;11(7):e0159867. [Content Brief]

[3]. du Toit T, et al. Profiling adrenal 11β-hydroxyandrostenedione metabolites in prostate cancer cells, tissue and plasma: UPC2-MS/MS quantification of 11β-hydroxytestosterone, 11keto-testosterone and 11keto-dihydrotestosterone. J Steroid Biochem Mol Biol. 2017 Feb;166:54-67. [Content Brief]

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

DMSO	1 mM	3.2527 mL	16.2633 mL	32.5267 mL	81.3167 mL
	5 mM	0.6505 mL	3.2527 mL	6.5053 mL	16.2633 mL
	10 mM	0.3253 mL	1.6263 mL	3.2527 mL	8.1317 mL
	15 mM	0.2168 mL	1.0842 mL	2.1684 mL	5.4211 mL
	20 mM	0.1626 mL	0.8132 mL	1.6263 mL	4.0658 mL
	25 mM	0.1301 mL	0.6505 mL	1.3011 mL	3.2527 mL
	30 mM	0.1084 mL	0.5421 mL	1.0842 mL	2.7106 mL
	40 mM	0.0813 mL	0.4066 mL	0.8132 mL	2.0329 mL
	50 mM	0.0651 mL	0.3253 mL	0.6505 mL	1.6263 mL
	60 mM	0.0542 mL	0.2711 mL	0.5421 mL	1.3553 mL
	80 mM	0.0407 mL	0.2033 mL	0.4066 mL	1.0165 mL
	100 mM	0.0325 mL	0.1626 mL	0.3253 mL	0.8132 mL

11-Ketodihydrotestosterone-d₃ Related Classifications

Endocrinology

Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

11-Ketodihydrotestosterone-d₃2479914-02-611-KDHT-d₃5α-Dihydro-11-keto testosterone-d₃Isotope-Labeled CompoundsAndrogen ReceptorInhibitorinhibitorinhibit

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11-Ketodihydrotestosterone-d3 (Synonyms: 11-KDHT-d3; 5α-Dihydro-11-keto testosterone-d3)

Other Forms of 11-Ketodihydrotestosterone-d3:

11-Ketodihydrotestosterone-d3 Related Antibodies