12β-Hydroxyisocholic acid (Synonyms: Lagocholic acid; 3α,7α,12β-Trihydroxy-5β-cholanic acid)

Cat. No.: HY-W587978 Purity: 99.66%: FAQs
Data Sheet SDS COA Handling Instructions

Molarity Calculator

12β-Hydroxyisocholic acid (Lagocholic acid) is a bile acid isomer that can be used in the study of bile acid metabolism.

For research use only. We do not sell to patients.

12β-Hydroxyisocholic acid Chemical Structure

CAS No. : 71883-64-2

Size	Stock	Quantity
1 mg	In-stock	Estimated Time of Arrival: December 31
5 mg	In-stock	Estimated Time of Arrival: December 31
10 mg	In-stock	Estimated Time of Arrival: December 31
50 mg	Get quote
100 mg	Get quote

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Other Forms of 12β-Hydroxyisocholic acid:

Cholic acid In-stock

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Purity & Documentation
References
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Description

12β-Hydroxyisocholic acid (Lagocholic acid) is a bile acid isomer that can be used in the study of bile acid metabolism^[1].

Molecular Weight

408.57

Formula

C₂₄H₄₀O₅

CAS No.

71883-64-2

Appearance

Solid

Color

White to off-white

SMILES

O[C@H]1[C@@]2([H])[C@@]3([H])[C@@]([C@@](CC3)([H])[C@H](C)CCC(O)=O)([C@@H](C[C@]2([H])[C@@]4([C@](C[C@@H](CC4)O)([H])C1)C)O)C

Structure Classification

Steroids

Initial Source

Endogenous metabolite

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Powder	-20°C	3 years
In solvent	-80°C	6 months
	-20°C	1 month

Solvent & Solubility

In Vitro:

DMSO : 100 mg/mL (244.76 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	2.4476 mL	12.2378 mL	24.4756 mL
5 mM	0.4895 mL	2.4476 mL	4.8951 mL
10 mM	0.2448 mL	1.2238 mL	2.4476 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Molarity Calculator
Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Concentration _(start)

Volume _(start)

Concentration _(final)

Volume _(final)

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Calculation results:

Working solution concentration: mg/mL

Purity & Documentation

Purity: 99.66%

Select Batch:

Data Sheet (270 KB) SDS (394 KB)

COA (251 KB) HNMR (261 KB) RP-HPLC (240 KB) MS (85 KB)

Handling Instructions (2659 KB)

References

[1]. Zhu P, et al. Analysis of human C24 bile acids metabolome in serum and urine based on enzyme digestion of conjugated bile acids and LC-MS determination of unconjugated bile acids. Anal Bioanal Chem. 2018 Aug;410(21):5287-5300. [Content Brief]

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

DMSO	1 mM	2.4476 mL	12.2378 mL	24.4756 mL	61.1890 mL
	5 mM	0.4895 mL	2.4476 mL	4.8951 mL	12.2378 mL
	10 mM	0.2448 mL	1.2238 mL	2.4476 mL	6.1189 mL
	15 mM	0.1632 mL	0.8159 mL	1.6317 mL	4.0793 mL
	20 mM	0.1224 mL	0.6119 mL	1.2238 mL	3.0595 mL
	25 mM	0.0979 mL	0.4895 mL	0.9790 mL	2.4476 mL
	30 mM	0.0816 mL	0.4079 mL	0.8159 mL	2.0396 mL
	40 mM	0.0612 mL	0.3059 mL	0.6119 mL	1.5297 mL
	50 mM	0.0490 mL	0.2448 mL	0.4895 mL	1.2238 mL
	60 mM	0.0408 mL	0.2040 mL	0.4079 mL	1.0198 mL
	80 mM	0.0306 mL	0.1530 mL	0.3059 mL	0.7649 mL
	100 mM	0.0245 mL	0.1224 mL	0.2448 mL	0.6119 mL

12β-Hydroxyisocholic acid Related Classifications

Metabolic Disease

Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

12β-Hydroxyisocholic acid71883-64-2Lagocholic acid 3α,7α,12β-Trihydroxy-5β-cholanic acidEndogenous Metabolitebile acidsisomerInhibitorinhibitorinhibit

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