16α-Hydroxy-11-keto prednisolone

Cat. No.: HY-W778340: FAQs
Data Sheet Handling Instructions Technical Support

16α-Hydroxy-11-keto prednisolone (compound M-X) is a metabolite of Budesonide (HY-13580). Budesonide, an inhaled glucocortical steroid, is an orally active glucocorticoid receptor agonist. Budesonide is a widely used for study of asthma, rhinitis, and inflammatory bowel disease.

For research use only. We do not sell to patients.

16α-Hydroxy-11-keto prednisolone Chemical Structure

CAS No. : 3754-05-0

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Biological Activity
Purity & Documentation
References
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Description

Molecular Weight

374.43

Formula

C₂₁H₂₆O₆

CAS No.

3754-05-0

SMILES

C[C@@]12[C@](C[C@H]([C@]2(O)C(CO)=O)O)([H])[C@@]3([H])[C@]([C@@]4(C(CC3)=CC(C=C4)=O)C)([H])C(C1)=O

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Solvent & Solubility

In Vitro:

DMSO : 116.67 mg/mL (311.59 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	2.6707 mL	13.3536 mL	26.7073 mL
5 mM	0.5341 mL	2.6707 mL	5.3415 mL
10 mM	0.2671 mL	1.3354 mL	2.6707 mL

View the Complete Stock Solution Preparation Table

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Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Concentration _(start)

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Concentration _(final)

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In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Calculation results:

Working solution concentration: mg/mL

Purity & Documentation

Handling Instructions (2659 KB)

References

[1]. Matabosch X, et al. Identification of budesonide metabolites in human urine after oral administration. Anal Bioanal Chem. 2012 Aug;404(2):325-40. [Content Brief]

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

DMSO	1 mM	2.6707 mL	13.3536 mL	26.7073 mL	66.7682 mL
	5 mM	0.5341 mL	2.6707 mL	5.3415 mL	13.3536 mL
	10 mM	0.2671 mL	1.3354 mL	2.6707 mL	6.6768 mL
	15 mM	0.1780 mL	0.8902 mL	1.7805 mL	4.4512 mL
	20 mM	0.1335 mL	0.6677 mL	1.3354 mL	3.3384 mL
	25 mM	0.1068 mL	0.5341 mL	1.0683 mL	2.6707 mL
	30 mM	0.0890 mL	0.4451 mL	0.8902 mL	2.2256 mL
	40 mM	0.0668 mL	0.3338 mL	0.6677 mL	1.6692 mL
	50 mM	0.0534 mL	0.2671 mL	0.5341 mL	1.3354 mL
	60 mM	0.0445 mL	0.2226 mL	0.4451 mL	1.1128 mL
	80 mM	0.0334 mL	0.1669 mL	0.3338 mL	0.8346 mL
	100 mM	0.0267 mL	0.1335 mL	0.2671 mL	0.6677 mL