2. Metabolic Enzyme/Protease
  3. Endogenous Metabolite
  4. 17β-HSD10-IN-1

17β-HSD10-IN-1 (compound 9) is an orally active inhibitor of 17β-hydroxysteroid dehydrogenase type 10 (17β-HSD10) with blood-brain permeability. 17β-HSD10-IN-1 doesn't result additional effects for mitochondrial off-targets and cytotoxic or neurotoxic effects.

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17β-HSD10-IN-1 Chemical Structure

17β-HSD10-IN-1 Chemical Structure

CAS No. : 2316765-78-1

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10 mg USD 120 In-stock
25 mg USD 240 In-stock
50 mg USD 385 In-stock
100 mg USD 615 In-stock
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Based on 1 publication(s) in Google Scholar

17β-HSD10-IN-1 Related Antibodies

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Description

17β-HSD10-IN-1 (compound 9) is an orally active inhibitor of 17β-hydroxysteroid dehydrogenase type 10 (17β-HSD10) with blood-brain permeability. 17β-HSD10-IN-1 doesn't result additional effects for mitochondrial off-targets and cytotoxic or neurotoxic effects[1].

IC50 & Target

17β-HSD10[1]
Molecular Weight

376.82

Formula

C16H13ClN4O3S
CAS No.
Appearance

Solid

Color

Pale purple to purple

SMILES

O=C(NC1=CC=C(C(Cl)=C1)O)NC(SC2=C3)=NC2=CC=C3NC(C)=O
Structure Classification
Initial Source
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 25 mg/mL (66.34 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.6538 mL 13.2689 mL 26.5379 mL
5 mM 0.5308 mL 2.6538 mL 5.3076 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

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In Vivo Dissolution Calculator
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Working solution concentration: mg/mL
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 2.6538 mL 13.2689 mL 26.5379 mL 66.3447 mL
5 mM 0.5308 mL 2.6538 mL 5.3076 mL 13.2689 mL
10 mM 0.2654 mL 1.3269 mL 2.6538 mL 6.6345 mL
15 mM 0.1769 mL 0.8846 mL 1.7692 mL 4.4230 mL
20 mM 0.1327 mL 0.6634 mL 1.3269 mL 3.3172 mL
25 mM 0.1062 mL 0.5308 mL 1.0615 mL 2.6538 mL
30 mM 0.0885 mL 0.4423 mL 0.8846 mL 2.2115 mL
40 mM 0.0663 mL 0.3317 mL 0.6634 mL 1.6586 mL
50 mM 0.0531 mL 0.2654 mL 0.5308 mL 1.3269 mL
60 mM 0.0442 mL 0.2211 mL 0.4423 mL 1.1057 mL
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17β-HSD10-IN-1 Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

17β-HSD10-IN-12316765-78-1Endogenous MetaboliteInhibitorinhibitorinhibit

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