18-Crown-6-ether (Synonyms: 18C6; 1,4,7,10,13,16-Hexaoxacyclooctadecane)

Cat. No.: HY-D0180 Purity: 98.30%: FAQs
Data Sheet SDS COA Handling Instructions

Molarity Calculator

18-Crown-6-ether (18C6; 1,4,7,10,13,16-Hexaoxacyclooctadecane) is an organic compound that can be used to prepare stable microcapsule responsive layers for further assembly into bilayer microcapsules. For example, 18-Crown-6-ether is used to prepare the response layer and is coated with a G-quadruplex cross-linked hydrogel layer stabilized by K⁺; when Mg²⁺ ions are present, 18-Crown-6-ether and K⁺ ions can respectively Dissociates and locks with the G-quadruplex cross-linked layer, thereby achieving switchable controlled release of the load.

For research use only. We do not sell to patients.

18-Crown-6-ether Chemical Structure

CAS No. : 17455-13-9

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100 g	USD 25	In-stock	Estimated Time of Arrival: December 31
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Biological Activity
Purity & Documentation
References
Customer Review

Description

Cellular Effect

Cell Line	Type	Value	Description	References
HeLa	IC₅₀	> 100 μM Compound: 1	Antiproliferative activity against HeLa cells after 72 hrs by MTT assay Antiproliferative activity against HeLa cells after 72 hrs by MTT assay	[PMID: 17300184]
MCF7	IC₅₀	> 100 μM Compound: 1	Antiproliferative activity against MCF7 cells after 72 hrs by MTT assay Antiproliferative activity against MCF7 cells after 72 hrs by MTT assay	[PMID: 17300184]
MIA PaCa-2	IC₅₀	> 100 μM Compound: 1	Antiproliferative activity against MiaPaCa2 cells after 72 hrs by MTT assay Antiproliferative activity against MiaPaCa2 cells after 72 hrs by MTT assay	[PMID: 17300184]
NCI-H460	IC₅₀	> 100 μM Compound: 1	Antiproliferative activity against H460 cells after 72 hrs by MTT assay Antiproliferative activity against H460 cells after 72 hrs by MTT assay	[PMID: 17300184]
SW-620	IC₅₀	> 100 μM Compound: 1	Antiproliferative activity against SW620 cells after 72 hrs by MTT assay Antiproliferative activity against SW620 cells after 72 hrs by MTT assay	[PMID: 17300184]

Molecular Weight

264.32

Formula

C₁₂H₂₄O₆

CAS No.

17455-13-9

Appearance

<42°C Solid,>45°C Liquid

Color

Colorless to white

SMILES

O1CCOCCOCCOCCOCCOCC1

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

4°C, sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

Solvent & Solubility

In Vitro:

DMSO : ≥ 100 mg/mL (378.33 mM; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

*"≥" means soluble, but saturation unknown.

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	3.7833 mL	18.9165 mL	37.8329 mL
5 mM	0.7567 mL	3.7833 mL	7.5666 mL
10 mM	0.3783 mL	1.8916 mL	3.7833 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Molarity Calculator
Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Concentration _(start)

Volume _(start)

Concentration _(final)

Volume _(final)

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Calculation results:

Working solution concentration: mg/mL

Purity & Documentation

Purity: 99.57%

Select Batch:

Data Sheet (275 KB) SDS (393 KB)

COA (254 KB) HNMR (107 KB) GC (211 KB)

Handling Instructions (2659 KB)

References

[1]. Lilienthal S, et al. Single and Bilayer Polyacrylamide Hydrogel-Based Microcapsules for the Triggered Release of Loads, Logic Gate Operations, and Intercommunication between Microcapsules. ACS Appl Mater Interfaces. 2020 Jul 15;12(28):31124-31136. [Content Brief]

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

DMSO	1 mM	3.7833 mL	18.9165 mL	37.8329 mL	94.5823 mL
	5 mM	0.7567 mL	3.7833 mL	7.5666 mL	18.9165 mL
	10 mM	0.3783 mL	1.8916 mL	3.7833 mL	9.4582 mL
	15 mM	0.2522 mL	1.2611 mL	2.5222 mL	6.3055 mL
	20 mM	0.1892 mL	0.9458 mL	1.8916 mL	4.7291 mL
	25 mM	0.1513 mL	0.7567 mL	1.5133 mL	3.7833 mL
	30 mM	0.1261 mL	0.6305 mL	1.2611 mL	3.1527 mL
	40 mM	0.0946 mL	0.4729 mL	0.9458 mL	2.3646 mL
	50 mM	0.0757 mL	0.3783 mL	0.7567 mL	1.8916 mL
	60 mM	0.0631 mL	0.3153 mL	0.6305 mL	1.5764 mL
	80 mM	0.0473 mL	0.2365 mL	0.4729 mL	1.1823 mL
	100 mM	0.0378 mL	0.1892 mL	0.3783 mL	0.9458 mL

18-Crown-6-ether Related Classifications

Others

Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

18-Crown-6-ether17455-13-918C6 1,4,7,10,13,16-HexaoxacyclooctadecaneBiochemical Assay ReagentsDouble-layer microcapsules,DNA nanotechnologyInhibitorinhibitorinhibit

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