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  4. (1R,3S)-Compound E

(1R,3S)-Compound E is the isomer of Compound E (HY-14176), and can be used as an experimental control. Compound E is a γ-secretase inhibitor. Compound E bloks β-amyloid(40), β-amyloid(42), and Notch γ-secretase cleavage with IC50s of 0.24, 0.37, 0.32 nM, respectively.

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(1R,3S)-Compound E Chemical Structure

(1R,3S)-Compound E Chemical Structure

CAS No. : 504428-17-5

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10 mg USD 920 In-stock
25 mg USD 1900 In-stock
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Based on 1 publication(s) in Google Scholar

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(1R,3S)-Compound E Related Antibodies

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Description

(1R,3S)-Compound E is the isomer of Compound E (HY-14176), and can be used as an experimental control. Compound E is a γ-secretase inhibitor. Compound E bloks β-amyloid(40), β-amyloid(42), and Notch γ-secretase cleavage with IC50s of 0.24, 0.37, 0.32 nM, respectively.

Molecular Weight

490.50

Formula

C27H24F2N4O3
CAS No.
Appearance

Solid

Color

White to off-white

SMILES

FC1=CC(F)=CC(CC(N[C@H](C)C(N[C@H]2N=C(C3=CC=CC=C3)C4=CC=CC=C4N(C2=O)C)=O)=O)=C1
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

-20°C, protect from light

*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

Solvent & Solubility
In Vitro: 

DMSO : ≥ 50 mg/mL (101.94 mM; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

*"≥" means soluble, but saturation unknown.

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.0387 mL 10.1937 mL 20.3874 mL
5 mM 0.4077 mL 2.0387 mL 4.0775 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

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V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 2.0387 mL 10.1937 mL 20.3874 mL 50.9684 mL
5 mM 0.4077 mL 2.0387 mL 4.0775 mL 10.1937 mL
10 mM 0.2039 mL 1.0194 mL 2.0387 mL 5.0968 mL
15 mM 0.1359 mL 0.6796 mL 1.3592 mL 3.3979 mL
20 mM 0.1019 mL 0.5097 mL 1.0194 mL 2.5484 mL
25 mM 0.0815 mL 0.4077 mL 0.8155 mL 2.0387 mL
30 mM 0.0680 mL 0.3398 mL 0.6796 mL 1.6989 mL
40 mM 0.0510 mL 0.2548 mL 0.5097 mL 1.2742 mL
50 mM 0.0408 mL 0.2039 mL 0.4077 mL 1.0194 mL
60 mM 0.0340 mL 0.1699 mL 0.3398 mL 0.8495 mL
80 mM 0.0255 mL 0.1274 mL 0.2548 mL 0.6371 mL
100 mM 0.0204 mL 0.1019 mL 0.2039 mL 0.5097 mL
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(1R,3S)-Compound E Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

(1R,3S)-Compound E504428-17-5OthersInhibitorinhibitorinhibit

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