2,2'-Bipyridine

Name: 2,2'-Bipyridine
Brand: MedChemExpress
SKU: HY-D0020
Rating: 4.5 (1 reviews)

Cat. No.: HY-D0020 Purity: 99.90%: FAQs
Data Sheet SDS COA Handling Instructions

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2,2'-Bipyridine is the unique molecular scaffold of the bioactive natural products. 2,2'-Bipyridine is extensively used as the core structure of many chelating ligands by acting as a bridge in the arrangement of the catalytic center. 2,2'-Bipyridine shows robust redox stability and hyperglycemic activity.

For research use only. We do not sell to patients.

2,2'-Bipyridine Chemical Structure

CAS No. : 366-18-7

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Solid + Solvent (Highly Recommended)
10 mM * 1 mL in DMSO ready for reconstitution	USD 55	In-stock	Estimated Time of Arrival: December 31
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10 mM * 1 mL in DMSO	USD 55	In-stock	Estimated Time of Arrival: December 31
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100 mg	USD 50	In-stock	Estimated Time of Arrival: December 31
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Based on 1 publication(s) in Google Scholar

Other Forms of 2,2'-Bipyridine:

2,2'-Bipyridine (Standard) Get quote

1 Publications Citing Use of MCE 2,2'-Bipyridine

•J Photochem Photobiol B. 2024 Aug 30:259:113023. [Abstract]

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Biological Activity
Purity & Documentation
References
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Description

Cellular Effect

Cell Line	Type	Value	Description	References
COS-7	IC₅₀	126 μM Compound: Bip	Displacement of [125I]-CCL3 from human CCR1 transfected in COS7 cells coexpressing chimeric Gqi4myr after 3 hrs Displacement of [125I]-CCL3 from human CCR1 transfected in COS7 cells coexpressing chimeric Gqi4myr after 3 hrs	[PMID: 22957890]
COS-7	EC₅₀	19 μM Compound: Bip	Allosteric modulation at human CCR5 transfected in COS7 cells coexpressing chimeric Gqi4myr assessed as [3H]IP3 turnover by liquid scintillation counting analysis Allosteric modulation at human CCR5 transfected in COS7 cells coexpressing chimeric Gqi4myr assessed as [3H]IP3 turnover by liquid scintillation counting analysis	[PMID: 22957890]
COS-7	EC₅₀	34 μM Compound: Bip	Allosteric modulation at human CCR1 transfected in COS7 cells coexpressing chimeric Gqi4myr assessed as {3H]IP3 turnover by liquid scintillation counting analysis Allosteric modulation at human CCR1 transfected in COS7 cells coexpressing chimeric Gqi4myr assessed as {3H]IP3 turnover by liquid scintillation counting analysis	[PMID: 22957890]
COS-7	EC₅₀	42 μM Compound: Bip	Allosteric modulation at human CCR8 transfected in COS7 cells assessed as [3H]IP3 turnover by liquid scintillation counting analysis Allosteric modulation at human CCR8 transfected in COS7 cells assessed as [3H]IP3 turnover by liquid scintillation counting analysis	[PMID: 22957890]
COS-7	IC₅₀	84 μM Compound: Bip	Displacement of [125I]-CCL3 from human CCR5 transfected in COS7 cells coexpressing chimeric Gqi4myr after 3 hrs Displacement of [125I]-CCL3 from human CCR5 transfected in COS7 cells coexpressing chimeric Gqi4myr after 3 hrs	[PMID: 22957890]
HUVEC	EC₅₀	10 μM Compound: 2,2'-bipyridine	Antiproliferative activity against HUVEC after 30 hrs by [3H]-thymidine incorporation assay Antiproliferative activity against HUVEC after 30 hrs by [3H]-thymidine incorporation assay	[PMID: 23634668]

In Vivo

2,2'-Bipyridine (40 mg/kg; s.c.; once) produces an initial hyperglycemia (an increase of 53.8 mg/100 mL at 2 hours) followed by a transient hypoglycemicphase at 24 hours and does not produce permanent diabetes^[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:	Male Holtzman rats (6-8 weeks old)^[2].
Dosage:	40 mg/kg
Administration:	Subcutaneous injection; once.
Result:	Showed hyperglycemic activity.

Molecular Weight

156.18

Formula

C₁₀H₈N₂

CAS No.

366-18-7

Appearance

Solid

Color

White to off-white

SMILES

C1(C2=NC=CC=C2)=NC=CC=C1

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Store at room temperature 3 years

In solvent	-80°C	2 years
	-20°C	1 year

Solvent & Solubility

In Vitro:

DMSO : 100 mg/mL (640.29 mM; ultrasonic and warming and heat to 60°C; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	6.4029 mL	32.0143 mL	64.0287 mL
5 mM	1.2806 mL	6.4029 mL	12.8057 mL
10 mM	0.6403 mL	3.2014 mL	6.4029 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.

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Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Concentration _(start)

Volume _(start)

Concentration _(final)

Volume _(final)

In Vivo:

Select the appropriate dissolution method based on your experimental animal and administration route.

For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for in vivo experiments, it is recommended to prepare freshly and use it on the same day.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

Protocol 1

Add each solvent one by one: 10% DMSO 40% PEG300 5% Tween-80 45% Saline
Solubility: ≥ 3 mg/mL (19.21 mM); Clear solution

This protocol yields a clear solution of ≥ 3 mg/mL (saturation unknown).
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (30.0 mg/mL) to 400 μL PEG300, and mix evenly; then add 50 μL Tween-80 and mix evenly; then add 450 μL Saline to adjust the volume to 1 mL.
Preparation of Saline: Dissolve 0.9 g sodium chloride in ddH₂O and dilute to 100 mL to obtain a clear Saline solution.
Protocol 2

Add each solvent one by one: 10% DMSO 90% (20% SBE-β-CD in Saline)
Solubility: ≥ 3 mg/mL (19.21 mM); Clear solution

This protocol yields a clear solution of ≥ 3 mg/mL (saturation unknown).
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (30.0 mg/mL) to 900 μL 20% SBE-β-CD in Saline, and mix evenly.
Preparation of 20% SBE-β-CD in Saline (4°C, storage for one week): 2 g SBE-β-CD powder is dissolved in 10 mL Saline, completely dissolve until clear.
Protocol 3

Add each solvent one by one: 10% DMSO 90% Corn Oil
Solubility: ≥ 3 mg/mL (19.21 mM); Clear solution

This protocol yields a clear solution of ≥ 3 mg/mL (saturation unknown). If the continuous dosing period exceeds half a month, please choose this protocol carefully.
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (30.0 mg/mL) to 900 μL Corn oil, and mix evenly.

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Please enter your animal formula composition:

DMSO +

Tween-80 +

Saline

Recommended: Keep the proportion of DMSO in working solution below 2% if your animal is weak.

The co-solvents required include: DMSO, . All of co-solvents are available by MedChemExpress (MCE). , Tween 80. All of co-solvents are available by MedChemExpress (MCE).

Calculation results:

Working solution concentration: mg/mL

Method for preparing stock solution: mg drug dissolved in μL DMSO (Stock solution concentration: mg/mL).

The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only. If necessary, please contact MedChemExpress (MCE).

Method for preparing in vivo working solution for animal experiments: Take μL DMSO stock solution, add μL . μL , mix evenly, next add μL Tween 80, mix evenly, then add μL Saline.

If the continuous dosing period exceeds half a month, please choose this protocol carefully.

Please ensure that the stock solution in the first step is dissolved to a clear state, and add co-solvents in sequence. You can use ultrasonic heating (ultrasonic cleaner, recommended frequency 20-40 kHz), vortexing, etc. to assist dissolution.

Purity & Documentation

Purity: 99.90%

Select Batch:

Data Sheet (275 KB) SDS (480 KB)

COA (251 KB) HNMR (115 KB) RP-HPLC (177 KB)

Handling Instructions (2659 KB)

References

[1]. Chen D, et al. Discovery of caerulomycin/collismycin-type 2,2'-bipyridine natural products in the genomic era. J Ind Microbiol Biotechnol. 2019;46(3-4):459-468. [Content Brief]

[2]. Kenny A D, et al. The hyperglycemic activity of 2, 2'-bipyridine[J]. Journal of Pharmacology and Experimental Therapeutics, 1962, 135(3): 317-322.

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

DMSO	1 mM	6.4029 mL	32.0143 mL	64.0287 mL	160.0717 mL
	5 mM	1.2806 mL	6.4029 mL	12.8057 mL	32.0143 mL
	10 mM	0.6403 mL	3.2014 mL	6.4029 mL	16.0072 mL
	15 mM	0.4269 mL	2.1343 mL	4.2686 mL	10.6714 mL
	20 mM	0.3201 mL	1.6007 mL	3.2014 mL	8.0036 mL
	25 mM	0.2561 mL	1.2806 mL	2.5611 mL	6.4029 mL
	30 mM	0.2134 mL	1.0671 mL	2.1343 mL	5.3357 mL
	40 mM	0.1601 mL	0.8004 mL	1.6007 mL	4.0018 mL
	50 mM	0.1281 mL	0.6403 mL	1.2806 mL	3.2014 mL
	60 mM	0.1067 mL	0.5336 mL	1.0671 mL	2.6679 mL
	80 mM	0.0800 mL	0.4002 mL	0.8004 mL	2.0009 mL
	100 mM	0.0640 mL	0.3201 mL	0.6403 mL	1.6007 mL

2,2'-Bipyridine Related Classifications

Infection Endocrinology

Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

2,2'-Bipyridine366-18-7Biochemical Assay ReagentsmolecularscaffoldcaerulomycinscollismycinschelatingligandshyperglycemicInhibitorinhibitorinhibit

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2,2'-Bipyridine

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Other Forms of 2,2'-Bipyridine:

2,2'-Bipyridine Related Antibodies

1 Publications Citing Use of MCE 2,2'-Bipyridine

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Complete Stock Solution Preparation Table

2,2'-Bipyridine Related Classifications

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