2. Metabolic Enzyme/Protease Immunology/Inflammation
  3. Endogenous Metabolite STING IFNAR
  4. 2',3'-cGAMP sodium

2',3'-cGAMP sodium  (Synonyms: 2'-3'-cyclic GMP-AMP sodium)

Cat. No.: HY-100564A Purity: 99.63%
COA Handling Instructions

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2',3'-cGAMP sodium (2'-3'-cyclic GMP-AMP sodium) is a endogenous cGAMP in mammalian cells. 2',3'-cGAMP sodium binds to STING with a high affinity and is a potent inducer of interferon-β (IFNβ). 2',3'-cGAMP sodium is produced in mammalian cells in response to DNA in the cytoplasm.

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2',3'-cGAMP sodium Chemical Structure

2',3'-cGAMP sodium Chemical Structure

CAS No. : 2734858-36-5

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1 mg USD 300 In-stock
5 mg USD 690 In-stock
10 mg USD 1250 In-stock
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Based on 13 publication(s) in Google Scholar

Other Forms of 2',3'-cGAMP sodium:

2',3'-cGAMP sodium Related Antibodies

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Description

2',3'-cGAMP sodium (2'-3'-cyclic GMP-AMP sodium) is a endogenous cGAMP in mammalian cells. 2',3'-cGAMP sodium binds to STING with a high affinity and is a potent inducer of interferon-β (IFNβ). 2',3'-cGAMP sodium is produced in mammalian cells in response to DNA in the cytoplasm[1].

IC50 & Target

STING, IFNβ[1]
In Vitro

2',3'-cGAMP sodium (2'-3'-cyclic GMP-AMP sodium) contains two distinct phosphodiester linkages, one between 2′-OH of GMP and 5′-phosphate of AMP, and the other between 3′-OH of AMP and 5′-phosphate of GMP[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

2',3'-cGAMP sodium Related Antibodies
Molecular Weight

718.37

Formula

C20H22N10Na2O13P2
CAS No.
Appearance

Solid

Color

White to off-white

SMILES

OC1([H])[C@](OP(OC[C@](O[C@@H](N2C3=NC=NC(N)=C3N=C2)[C@@H]4O)([H])[C@@]4([H])O5)(O[Na])=O)([H])[C@H](N6C(NC(N)=NC7=O)=C7N=C6)O[C@]1([H])COP5(O[Na])=O
Structure Classification
Initial Source
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

-20°C, sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

Solvent & Solubility
In Vitro: 

H2O : 50 mg/mL (69.60 mM; Need ultrasonic)

DMSO : < 1 mg/mL (insoluble or slightly soluble)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 1.3920 mL 6.9602 mL 13.9204 mL
5 mM 0.2784 mL 1.3920 mL 2.7841 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
×
Volume
×
Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

×
Volume (start)

V1

=
Concentration (final)

C2

×
Volume (final)

V2

In Vivo:

For the following dissolution methods, please prepare the working solution directly. It is recommended to prepare fresh solutions and use them promptly within a short period of time.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

  • Protocol 1

    Add each solvent one by one:  PBS

    Solubility: 18.33 mg/mL (25.52 mM); Clear solution; Need ultrasonic

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

mg/kg

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(per animal)

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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
This product has good water solubility, please refer to the measured solubility data in water/PBS/Saline for details.
The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only.If necessary, please contact MedChemExpress (MCE).
Purity & Documentation

Purity: 99.89%

COA (251 KB) HNMR (249 KB) LCMS (99 KB)

Handling Instructions (2659 KB)
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
H2O 1 mM 1.3920 mL 6.9602 mL 13.9204 mL 34.8010 mL
5 mM 0.2784 mL 1.3920 mL 2.7841 mL 6.9602 mL
10 mM 0.1392 mL 0.6960 mL 1.3920 mL 3.4801 mL
15 mM 0.0928 mL 0.4640 mL 0.9280 mL 2.3201 mL
20 mM 0.0696 mL 0.3480 mL 0.6960 mL 1.7401 mL
25 mM 0.0557 mL 0.2784 mL 0.5568 mL 1.3920 mL
30 mM 0.0464 mL 0.2320 mL 0.4640 mL 1.1600 mL
40 mM 0.0348 mL 0.1740 mL 0.3480 mL 0.8700 mL
50 mM 0.0278 mL 0.1392 mL 0.2784 mL 0.6960 mL
60 mM 0.0232 mL 0.1160 mL 0.2320 mL 0.5800 mL

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

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2',3'-cGAMP sodium Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

2',3'-cGAMP2734858-36-52'-3'-cyclic GMP-AMPEndogenous MetaboliteSTINGIFNARStimulator of Interferon GenesTMEM173MITAERISMPYSInterferon-α/β receptorInterferon-alpha/beta receptorendogenouscGAMPDNAIFNβInhibitorinhibitorinhibit

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