2. Metabolic Enzyme/Protease Immunology/Inflammation
  3. Endogenous Metabolite STING IFNAR
  4. 2',3'-cGAMP

2',3'-cGAMP  (Synonyms: 2'-3'-cyclic GMP-AMP)

Cat. No.: HY-100564 Purity: 99.95%
COA Handling Instructions

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2',3'-cGAMP (2'-3'-cyclic GMP-AMP) is a endogenous cGAMP in mammalian cells. 2',3'-cGAMP binds to STING with a high affinity and is a potent inducer of interferon-β (IFNβ). 2',3'-cGAMP is produced in mammalian cells in response to DNA in the cytoplasm.

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2',3'-cGAMP Chemical Structure

2',3'-cGAMP Chemical Structure

CAS No. : 1441190-66-4

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1 mg USD 300 In-stock
5 mg USD 690 In-stock
10 mg USD 1250 In-stock
25 mg USD 2500 In-stock
50 mg USD 4000 In-stock
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Based on 13 publication(s) in Google Scholar

Other Forms of 2',3'-cGAMP:

2',3'-cGAMP Related Antibodies

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Description

2',3'-cGAMP (2'-3'-cyclic GMP-AMP) is a endogenous cGAMP in mammalian cells. 2',3'-cGAMP binds to STING with a high affinity and is a potent inducer of interferon-β (IFNβ). 2',3'-cGAMP is produced in mammalian cells in response to DNA in the cytoplasm[1].

IC50 & Target

STING, IFNβ[1]
In Vitro

2',3'-cGAMP (2'-3'-cyclic GMP-AMP) contains two distinct phosphodiester linkages, one between 2′-OH of GMP and 5′-phosphate of AMP, and the other between 3′-OH of AMP and 5′-phosphate of GMP[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

2',3'-cGAMP Related Antibodies
Molecular Weight

674.41

Formula

C20H24N10O13P2
CAS No.
Appearance

Solid

Color

White to off-white

SMILES

OC1([H])[C@](OP(O)(OC[C@](O[C@@H](N2C3=NC=NC(N)=C3N=C2)[C@@H]4O)([H])[C@@]4([H])O5)=O)([H])[C@H](N6C(NC(N)=NC7=O)=C7N=C6)O[C@]1([H])COP5(O)=O
Structure Classification
Initial Source
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

-20°C, sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

Solvent & Solubility
In Vitro: 

H2O : ≥ 50 mg/mL (74.14 mM)

*"≥" means soluble, but saturation unknown.

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 1.4828 mL 7.4139 mL 14.8278 mL
5 mM 0.2966 mL 1.4828 mL 2.9656 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

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  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

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In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

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Calculation results:
Working solution concentration: mg/mL
This product has good water solubility, please refer to the measured solubility data in water/PBS/Saline for details.
The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only.If necessary, please contact MedChemExpress (MCE).
Purity & Documentation

Purity: 99.95%

COA (250 KB) HNMR (241 KB) RP-HPLC (204 KB)

Handling Instructions (2659 KB)
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
H2O 1 mM 1.4828 mL 7.4139 mL 14.8278 mL 37.0694 mL
5 mM 0.2966 mL 1.4828 mL 2.9656 mL 7.4139 mL
10 mM 0.1483 mL 0.7414 mL 1.4828 mL 3.7069 mL
15 mM 0.0989 mL 0.4943 mL 0.9885 mL 2.4713 mL
20 mM 0.0741 mL 0.3707 mL 0.7414 mL 1.8535 mL
25 mM 0.0593 mL 0.2966 mL 0.5931 mL 1.4828 mL
30 mM 0.0494 mL 0.2471 mL 0.4943 mL 1.2356 mL
40 mM 0.0371 mL 0.1853 mL 0.3707 mL 0.9267 mL
50 mM 0.0297 mL 0.1483 mL 0.2966 mL 0.7414 mL
60 mM 0.0247 mL 0.1236 mL 0.2471 mL 0.6178 mL

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

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2',3'-cGAMP Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

2',3'-cGAMP1441190-66-42'-3'-cyclic GMP-AMPEndogenous MetaboliteSTINGIFNARStimulator of Interferon GenesTMEM173MITAERISMPYSInterferon-α/β receptorInterferon-alpha/beta receptorendogenouscGAMPDNAIFNβInhibitorinhibitorinhibit

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