2’-Azido-2’-deoxycytidine

Cat. No.: HY-152448 Purity: 98.78%: FAQs
Data Sheet SDS COA Handling Instructions

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2’-Azido-2’-deoxycytidine is a purine nucleoside analogue. Purine nucleoside analogs have broad antitumor activity targeting indolent lymphoid malignancies. Anticancer mechanisms in this process rely on inhibition of DNA synthesis, induction of apoptosis, etc. 2’-Azido-2’-deoxycytidine is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups. 2’-Azido-2’-deoxycytidine is an azidonucleoside,and it should be phosphorylated twice to become an inhibitor of the nucleotide reductase.

For research use only. We do not sell to patients.

2’-Azido-2’-deoxycytidine Chemical Structure

CAS No. : 51034-68-5

Size	Price	Stock	Quantity
5 mg	USD 235	In-stock	Estimated Time of Arrival: December 31
10 mg	USD 400	In-stock	Estimated Time of Arrival: December 31
50 mg		Get quote
100 mg		Get quote

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Biological Activity
Purity & Documentation
References
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Description

2’-Azido-2’-deoxycytidine is a purine nucleoside analogue. Purine nucleoside analogs have broad antitumor activity targeting indolent lymphoid malignancies. Anticancer mechanisms in this process rely on inhibition of DNA synthesis, induction of apoptosis, etc^[1]. 2’-Azido-2’-deoxycytidine is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups. 2’-Azido-2’-deoxycytidine is an azidonucleoside,and it should be phosphorylated twice to become an inhibitor of the nucleotide reductase.

Molecular Weight

268.23

Formula

C₉H₁₂N₆O₄

CAS No.

51034-68-5

Appearance

Solid

Color

White to off-white

SMILES

OC[C@@H]1[C@@H](O)[C@@H](N=[N+]=[N-])[C@H](N2C(N=C(N)C=C2)=O)O1

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Powder	-20°C	3 years
	4°C	2 years
In solvent	-80°C	6 months
	-20°C	1 month

Solvent & Solubility

In Vitro:

DMSO : 250 mg/mL (932.04 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	3.7281 mL	18.6407 mL	37.2814 mL
5 mM	0.7456 mL	3.7281 mL	7.4563 mL
10 mM	0.3728 mL	1.8641 mL	3.7281 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

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Concentration _(final)

Volume _(final)

In Vivo Dissolution Calculator

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Calculation results:

Working solution concentration: mg/mL

Purity & Documentation

Purity: 98.78%

Select Batch:

Data Sheet (272 KB) SDS (251 KB)

COA (249 KB) HNMR (256 KB) LCMS (94 KB)

Handling Instructions (2659 KB)

References

[1]. Robak T, Robak P. Purine nucleoside analogs in the treatment of rarer chronic lymphoid leukemias. Curr Pharm Des. 2012;18(23):3373-3388. [Content Brief]

[2]. Kang SH, Cho MJ. Biological activity and phosphorylation of 2'-azido-2'-deoxyuridine and 2'-azido-2'-deoxycytidine. Nucleosides Nucleotides. 1998;17(6):1077-1088. [Content Brief]

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

DMSO	1 mM	3.7281 mL	18.6407 mL	37.2814 mL	93.2036 mL
	5 mM	0.7456 mL	3.7281 mL	7.4563 mL	18.6407 mL
	10 mM	0.3728 mL	1.8641 mL	3.7281 mL	9.3204 mL
	15 mM	0.2485 mL	1.2427 mL	2.4854 mL	6.2136 mL
	20 mM	0.1864 mL	0.9320 mL	1.8641 mL	4.6602 mL
	25 mM	0.1491 mL	0.7456 mL	1.4913 mL	3.7281 mL
	30 mM	0.1243 mL	0.6214 mL	1.2427 mL	3.1068 mL
	40 mM	0.0932 mL	0.4660 mL	0.9320 mL	2.3301 mL
	50 mM	0.0746 mL	0.3728 mL	0.7456 mL	1.8641 mL
	60 mM	0.0621 mL	0.3107 mL	0.6214 mL	1.5534 mL
	80 mM	0.0466 mL	0.2330 mL	0.4660 mL	1.1650 mL
	100 mM	0.0373 mL	0.1864 mL	0.3728 mL	0.9320 mL