2. Cell Cycle/DNA Damage
  3. Nucleoside Antimetabolite/Analog
  4. 2’-Chloro-2’-deoxyadenosine

2’-Chloro-2’-deoxyadenosine 

Cat. No.: HY-152334 Purity: 98.53%
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2’-Chloro-2’-deoxyadenosine is a purine nucleoside analogue. Purine nucleoside analogs have broad antitumor activity targeting indolent lymphoid malignancies. Anticancer mechanisms in this process rely on inhibition of DNA synthesis, induction of apoptosis, etc.

For research use only. We do not sell to patients.

2’-Chloro-2’-deoxyadenosine Chemical Structure

2’-Chloro-2’-deoxyadenosine Chemical Structure

CAS No. : 2627-62-5

Size Price Stock Quantity
1 mg USD 120 In-stock
5 mg USD 300 In-stock
10 mg USD 490 In-stock
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100 mg   Get quote  

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Based on 1 publication(s) in Google Scholar

2’-Chloro-2’-deoxyadenosine Related Antibodies

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Description

2’-Chloro-2’-deoxyadenosine is a purine nucleoside analogue. Purine nucleoside analogs have broad antitumor activity targeting indolent lymphoid malignancies. Anticancer mechanisms in this process rely on inhibition of DNA synthesis, induction of apoptosis, etc[1].

Molecular Weight

285.69

Formula

C10H12ClN5O3
CAS No.
Appearance

Solid

Color

White to off-white

SMILES

O[C@H]1[C@@H](Cl)[C@H](N2C(N=CN=C3N)=C3N=C2)O[C@@H]1CO
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : ≥ 100 mg/mL (350.03 mM; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

*"≥" means soluble, but saturation unknown.

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 3.5003 mL 17.5015 mL 35.0030 mL
5 mM 0.7001 mL 3.5003 mL 7.0006 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
×
Volume
×
Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

×
Volume (start)

V1

=
Concentration (final)

C2

×
Volume (final)

V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

g

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 3.5003 mL 17.5015 mL 35.0030 mL 87.5074 mL
5 mM 0.7001 mL 3.5003 mL 7.0006 mL 17.5015 mL
10 mM 0.3500 mL 1.7501 mL 3.5003 mL 8.7507 mL
15 mM 0.2334 mL 1.1668 mL 2.3335 mL 5.8338 mL
20 mM 0.1750 mL 0.8751 mL 1.7501 mL 4.3754 mL
25 mM 0.1400 mL 0.7001 mL 1.4001 mL 3.5003 mL
30 mM 0.1167 mL 0.5834 mL 1.1668 mL 2.9169 mL
40 mM 0.0875 mL 0.4375 mL 0.8751 mL 2.1877 mL
50 mM 0.0700 mL 0.3500 mL 0.7001 mL 1.7501 mL
60 mM 0.0583 mL 0.2917 mL 0.5834 mL 1.4585 mL
80 mM 0.0438 mL 0.2188 mL 0.4375 mL 1.0938 mL
100 mM 0.0350 mL 0.1750 mL 0.3500 mL 0.8751 mL
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2’-Chloro-2’-deoxyadenosine Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

2’-Chloro-2’-deoxyadenosine2627-62-5Nucleoside Antimetabolite/Analogindolent lymphoid malignanciesantitumorInhibitorinhibitorinhibit

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