2. Cell Cycle/DNA Damage
  3. Nucleoside Antimetabolite/Analog
  4. 2-Chloro-2′-β-C-methyladenosine

2-Chloro-2′-β-C-methyladenosine is an adenosine analogue. Adenosine analogs mostly act as smooth muscle vasodilators and have also been shown to inhibit cancer progression. The popular products in this series are adenosine phosphate, Acadesine (HY-13417), Clofarabine (HY-A0005), Fludarabine phosphate (HY-B0028) and Vidarabine (HY-B0277).

For research use only. We do not sell to patients.

2-Chloro-2′-β-C-methyladenosine Chemical Structure

2-Chloro-2′-β-C-methyladenosine Chemical Structure

CAS No. : 205171-11-5

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2-Chloro-2′-β-C-methyladenosine Related Antibodies

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  • Biological Activity

  • Purity & Documentation

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Description

2-Chloro-2′-β-C-methyladenosine is an adenosine analogue. Adenosine analogs mostly act as smooth muscle vasodilators and have also been shown to inhibit cancer progression. The popular products in this series are adenosine phosphate, Acadesine (HY-13417), Clofarabine (HY-A0005), Fludarabine phosphate (HY-B0028) and Vidarabine (HY-B0277)[1].

Cellular Effect
Cell Line Type Value Description References
CCRF-CEM CC50
> 100 μM
Compound: 17
Cytotoxicity against human CEM cells after 6 days by trypan blue exclusion assay
Cytotoxicity against human CEM cells after 6 days by trypan blue exclusion assay
[PMID: 26819659]
CCRF-CEM CC50
> 100 μM
Compound: 17
Cytotoxicity against human CEM after 5 days
Cytotoxicity against human CEM after 5 days
[PMID: 21983447]
Huh-7 CC50
> 10 μM
Compound: 17
Cytotoxicity against human HuH7 cells infected with HCV assessed as reduction in cellular rRNA level after 96 hrs by qRT-PCR analysis
Cytotoxicity against human HuH7 cells infected with HCV assessed as reduction in cellular rRNA level after 96 hrs by qRT-PCR analysis
[PMID: 26819659]
PBMC CC50
> 100 μM
Compound: 17
Cytotoxicity against human PBMC after 6 days by trypan blue exclusion assay
Cytotoxicity against human PBMC after 6 days by trypan blue exclusion assay
[PMID: 26819659]
PBMC CC50
> 100 μM
Compound: 17
Cytotoxicity against human PBMC after 5 days
Cytotoxicity against human PBMC after 5 days
[PMID: 21983447]
Vero CC50
> 100 μM
Compound: 17
Cytotoxicity against African green monkey Vero cells after 3 days by hemocytometry
Cytotoxicity against African green monkey Vero cells after 3 days by hemocytometry
[PMID: 26819659]
Vero CC50
> 100 μM
Compound: 17
Cytotoxicity against african green monkey Vero after 5 days
Cytotoxicity against african green monkey Vero after 5 days
[PMID: 21983447]
Molecular Weight

315.71

Formula

C11H14ClN5O4
CAS No.
SMILES

OC[C@@H]1[C@@H](O)[C@](O)(C)[C@H](N2C=NC3=C(N)N=C(Cl)N=C32)O1
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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2-Chloro-2′-β-C-methyladenosine Related Classifications

  • Molarity Calculator

  • Dilution Calculator

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass   Concentration   Volume   Molecular Weight *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

2-Chloro-2′-β-C-methyladenosine205171-11-5Nucleoside Antimetabolite/Analogmuscle vasodilatorInhibitorinhibitorinhibit

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