1. Cell Cycle/DNA Damage Anti-infection
  2. DNA/RNA Synthesis Virus Protease
  3. 2'-Deoxy-2'-fluoro-l-uridine

2'-Deoxy-2'-fluoro-l-uridine is an L-nucleoside compound. 2'-Deoxy-2'-fluoro-l-uridine is a potent, selective viral RNA polymerase inhibitor, thereby inhibiting RNA virus replication.

For research use only. We do not sell to patients.

2'-Deoxy-2'-fluoro-l-uridine Chemical Structure

2'-Deoxy-2'-fluoro-l-uridine Chemical Structure

CAS No. : 622785-69-7

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Description

2'-Deoxy-2'-fluoro-l-uridine is an L-nucleoside compound. 2'-Deoxy-2'-fluoro-l-uridine is a potent, selective viral RNA polymerase inhibitor, thereby inhibiting RNA virus replication[1].

Cellular Effect
Cell Line Type Value Description References
HEp-2 EC50
> 100 μM
Compound: 2'd2'FU
Antiviral activity against RSV A2 infected in human Hep2 cells assessed as protection against virus-induced cytopathic effect after 4 days by Cell-Titer Glo assay
Antiviral activity against RSV A2 infected in human Hep2 cells assessed as protection against virus-induced cytopathic effect after 4 days by Cell-Titer Glo assay
[PMID: 25978965]
HEp-2 IC50
3.5 μM
Compound: 2'd2'FU
Inhibition of RSV A2 RNA-dependent RNA polymerase expressed in human Hep2 cells using ATP, GTP, UTP, CTP and 1.5 uCi [alpha-32P] NTP as substrate assessed as reduction of total radiolabled transcript after 90 mins by agarose gel electrophoresis
Inhibition of RSV A2 RNA-dependent RNA polymerase expressed in human Hep2 cells using ATP, GTP, UTP, CTP and 1.5 uCi [alpha-32P] NTP as substrate assessed as reduction of total radiolabled transcript after 90 mins by agarose gel electrophoresis
[PMID: 25978965]
Molecular Weight

246.19

Formula

C9H11FN2O5

CAS No.
SMILES

F[C@H]1[C@@H](O)[C@H](CO)O[C@@H]1N(C=CC(N2)=O)C2=O

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Room temperature in continental US; may vary elsewhere.

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Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation
References
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Product Name:
2'-Deoxy-2'-fluoro-l-uridine
Cat. No.:
HY-148167
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