2-Hydroxyethyl methacrylate

Name: 2-Hydroxyethyl methacrylate
Brand: MedChemExpress
SKU: HY-W012723
Rating: 4.5 (1 reviews)

Cat. No.: HY-W012723 Purity: 97.97%: FAQs
Data Sheet SDS COA Handling Instructions

Molarity Calculator

2-Hydroxyethyl methacrylate (HEMA) is a monomer used in the synthesis of various polymers, and the polymer PHEMA of 2-Hydroxyethyl methacrylate is widely used in the synthesis of dental composite materials.

For research use only. We do not sell to patients.

2-Hydroxyethyl methacrylate Chemical Structure

CAS No. : 868-77-9

Size	Price	Stock	Quantity
500 mg	USD 25	In-stock	Estimated Time of Arrival: December 31
1 g	USD 40	In-stock	Estimated Time of Arrival: December 31
5 g		Get quote
10 g		Get quote

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Based on 1 publication(s) in Google Scholar

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Biological Activity
Purity & Documentation
References
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Description

In Vitro

2-Hydroxyethyl methacrylate

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

130.14

Formula

C₆H₁₀O₃

CAS No.

868-77-9

Appearance

Liquid (Density: 1.073 g/cm³)

Color

Colorless to light yellow

SMILES

CC(C(OCCO)=O)=C

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

4°C, protect from light

*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

Solvent & Solubility

In Vitro:

DMSO : ≥ 100 mg/mL (768.40 mM; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

*"≥" means soluble, but saturation unknown.

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	7.6840 mL	38.4202 mL	76.8403 mL
5 mM	1.5368 mL	7.6840 mL	15.3681 mL
10 mM	0.7684 mL	3.8420 mL	7.6840 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Molarity Calculator
Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Concentration _(start)

Volume _(start)

Concentration _(final)

Volume _(final)

In Vivo:

Select the appropriate dissolution method based on your experimental animal and administration route.

For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for in vivo experiments, it is recommended to prepare freshly and use it on the same day.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

Protocol 1

Add each solvent one by one: 10% DMSO 40% PEG300 5% Tween-80 45% Saline
Solubility: ≥ 2.5 mg/mL (19.21 mM); Clear solution

This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown).
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 400 μL PEG300, and mix evenly; then add 50 μL Tween-80 and mix evenly; then add 450 μL Saline to adjust the volume to 1 mL.
Preparation of Saline: Dissolve 0.9 g sodium chloride in ddH₂O and dilute to 100 mL to obtain a clear Saline solution.
Protocol 2

Add each solvent one by one: 10% DMSO 90% (20% SBE-β-CD in Saline)
Solubility: ≥ 2.5 mg/mL (19.21 mM); Clear solution

This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown).
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 900 μL 20% SBE-β-CD in Saline, and mix evenly.
Preparation of 20% SBE-β-CD in Saline (4°C, storage for one week): 2 g SBE-β-CD powder is dissolved in 10 mL Saline, completely dissolve until clear.
Protocol 3

Add each solvent one by one: 10% DMSO 90% Corn Oil
Solubility: ≥ 2.5 mg/mL (19.21 mM); Clear solution

This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown). If the continuous dosing period exceeds half a month, please choose this protocol carefully.
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 900 μL Corn oil, and mix evenly.

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Please enter your animal formula composition:

DMSO +

Tween-80 +

Saline

Recommended: Keep the proportion of DMSO in working solution below 2% if your animal is weak.

The co-solvents required include: DMSO, . All of co-solvents are available by MedChemExpress (MCE). , Tween 80. All of co-solvents are available by MedChemExpress (MCE).

Calculation results:

Working solution concentration: mg/mL

Method for preparing stock solution: mg drug dissolved in μL DMSO (Stock solution concentration: mg/mL).

*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only. If necessary, please contact MedChemExpress (MCE).

Method for preparing in vivo working solution for animal experiments: Take μL DMSO stock solution, add μL . μL , mix evenly, next add μL Tween 80, mix evenly, then add μL Saline.

If the continuous dosing period exceeds half a month, please choose this protocol carefully.

Please ensure that the stock solution in the first step is dissolved to a clear state, and add co-solvents in sequence. You can use ultrasonic heating (ultrasonic cleaner, recommended frequency 20-40 kHz), vortexing, etc. to assist dissolution.

Purity & Documentation

Purity: 99.05%

Select Batch:

Data Sheet (268 KB) SDS (393 KB)

COA (243 KB) HNMR (119 KB) GC (213 KB)

Handling Instructions (2659 KB)

References

[1]. André Jochums, et al. Influence of 2-hydroxyethyl methacrylate (HEMA) exposure on angiogenic differentiation of dental pulp stem cells (DPSCs). Dent Mater. 2021 Mar;37(3):534-546. [Content Brief]

[2]. Montheard J P, et al. 2-hydroxyethyl methacrylate (HEMA): chemical properties and applications in biomedical fields[J]. Journal of Macromolecular Science, Part C: Polymer Reviews, 1992, 32(1): 1-34.

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

DMSO	1 mM	7.6840 mL	38.4202 mL	76.8403 mL	192.1008 mL
	5 mM	1.5368 mL	7.6840 mL	15.3681 mL	38.4202 mL
	10 mM	0.7684 mL	3.8420 mL	7.6840 mL	19.2101 mL
	15 mM	0.5123 mL	2.5613 mL	5.1227 mL	12.8067 mL
	20 mM	0.3842 mL	1.9210 mL	3.8420 mL	9.6050 mL
	25 mM	0.3074 mL	1.5368 mL	3.0736 mL	7.6840 mL
	30 mM	0.2561 mL	1.2807 mL	2.5613 mL	6.4034 mL
	40 mM	0.1921 mL	0.9605 mL	1.9210 mL	4.8025 mL
	50 mM	0.1537 mL	0.7684 mL	1.5368 mL	3.8420 mL
	60 mM	0.1281 mL	0.6403 mL	1.2807 mL	3.2017 mL
	80 mM	0.0961 mL	0.4803 mL	0.9605 mL	2.4013 mL
	100 mM	0.0768 mL	0.3842 mL	0.7684 mL	1.9210 mL