2. Others Metabolic Enzyme/Protease
  3. Isotope-Labeled Compounds Endogenous Metabolite
  4. 25-Hydroxycholesterol-d6

25-Hydroxycholesterol-d6  (Synonyms: 25-OHC-d6)

Cat. No.: HY-113134S Purity: 99%
COA Handling Instructions

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25-Hydroxycholesterol-d6 (25-OHC-d6) is the deuterium labeled 25-Hydroxycholesterol. 25-Hydroxycholesterol is a metabolite of cholesterol that is produced and secreted by macrophages in response to Toll-like receptor (TLR) activation. 25-hydroxycholesterol is a potent (EC50≈65 nM) and selective suppressor of IgA production by B cells[1][2].

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25-Hydroxycholesterol-d<sub>6</sub> Chemical Structure

25-Hydroxycholesterol-d6 Chemical Structure

CAS No. : 88247-69-2

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Based on 1 publication(s) in Google Scholar

Other Forms of 25-Hydroxycholesterol-d6:

25-Hydroxycholesterol-d6 Related Antibodies

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Description

25-Hydroxycholesterol-d6 (25-OHC-d6) is the deuterium labeled 25-Hydroxycholesterol. 25-Hydroxycholesterol is a metabolite of cholesterol that is produced and secreted by macrophages in response to Toll-like receptor (TLR) activation. 25-hydroxycholesterol is a potent (EC50≈65 nM) and selective suppressor of IgA production by B cells[1][2].

In Vitro

Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

25-Hydroxycholesterol-d6 Related Antibodies
Molecular Weight

408.69

Formula

C27H40D6O2
CAS No.
Unlabeled CAS

2140-46-7
Appearance

Solid

Color

White to off-white

SMILES

C[C@@]12[C@](CC[C@]2([H])[C@H](C)CCCC(C([2H])([2H])[2H])(O)C([2H])([2H])[2H])([H])[C@@]3([H])[C@@](CC1)([H])[C@@]4(C(C[C@H](CC4)O)=CC3)C
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Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

Ethanol : 14.29 mg/mL (34.97 mM; Need ultrasonic and warming)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.4468 mL 12.2342 mL 24.4684 mL
5 mM 0.4894 mL 2.4468 mL 4.8937 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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This equation is commonly abbreviated as: C1V1 = C2V2

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Working solution concentration: mg/mL
Purity & Documentation

Purity: 99%

COA (249 KB)

Handling Instructions (2659 KB)
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
Ethanol 1 mM 2.4468 mL 12.2342 mL 24.4684 mL 61.1711 mL
5 mM 0.4894 mL 2.4468 mL 4.8937 mL 12.2342 mL
10 mM 0.2447 mL 1.2234 mL 2.4468 mL 6.1171 mL
15 mM 0.1631 mL 0.8156 mL 1.6312 mL 4.0781 mL
20 mM 0.1223 mL 0.6117 mL 1.2234 mL 3.0586 mL
25 mM 0.0979 mL 0.4894 mL 0.9787 mL 2.4468 mL
30 mM 0.0816 mL 0.4078 mL 0.8156 mL 2.0390 mL
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25-Hydroxycholesterol-d6 Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

25-Hydroxycholesterol-d688247-69-225-OHC-d6Isotope-Labeled CompoundsEndogenous MetaboliteInhibitorinhibitorinhibit

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