2'-Deoxypseudoisocytidine

Cat. No.: HY-101968: FAQs
Data Sheet Handling Instructions

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2'-Deoxypseudoisocytidine is a nucleoside analogue.

For research use only. We do not sell to patients.

2'-Deoxypseudoisocytidine Chemical Structure

CAS No. : 65358-18-1

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Biological Activity
Purity & Documentation
References
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Description

2'-Deoxypseudoisocytidine is a nucleoside analogue.

In Vitro

2'-Deoxypseudoisocytidine is a modified base which can be used as a allele-specific blocker probe to discriminate sequence variation between different alleles and quantitate rare (e.g., mutant) allelic variants, such as SNPs, or nucleotide (NT) insertions or deletions, in samples comprising abundant allelic variants with high specificity and selectivity^[1]. 2'-Deoxypseudoisocytidine (2′d‐PIC) and its analogues are also used as novel base-pairing agents in oligonucleotides to investigate DNA and RNA structures and functions^[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

227.22

Formula

C₉H₁₃N₃O₄

CAS No.

65358-18-1

SMILES

NC(NC1=O)=NC=C1[C@H]2C[C@H](O)[C@@H](CO)O2

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Solvent & Solubility

In Vitro:

DMSO : ≥ 106.5 mg/mL (468.71 mM; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

*"≥" means soluble, but saturation unknown.

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	4.4010 mL	22.0051 mL	44.0102 mL
5 mM	0.8802 mL	4.4010 mL	8.8020 mL
10 mM	0.4401 mL	2.2005 mL	4.4010 mL

View the Complete Stock Solution Preparation Table

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Concentration _(start)

Volume _(start)

Concentration _(final)

Volume _(final)

In Vivo Dissolution Calculator

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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Calculation results:

Working solution concentration: mg/mL

Purity & Documentation

Handling Instructions (2659 KB)

References

[1]. Caifu Chen, et al. Methods, Compositions, and Kits for Detecting Allelic Variants. US 20100285478 A1.

[2]. Serpi M, et al. Synthetic Approaches for the Preparation of Phosphoramidate Prodrugs of 2'-Deoxypseudoisocytidine. ChemistryOpen. 2017 May 5;6(3):424-436. [Content Brief]

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

DMSO	1 mM	4.4010 mL	22.0051 mL	44.0102 mL	110.0255 mL
	5 mM	0.8802 mL	4.4010 mL	8.8020 mL	22.0051 mL
	10 mM	0.4401 mL	2.2005 mL	4.4010 mL	11.0026 mL
	15 mM	0.2934 mL	1.4670 mL	2.9340 mL	7.3350 mL
	20 mM	0.2201 mL	1.1003 mL	2.2005 mL	5.5013 mL
	25 mM	0.1760 mL	0.8802 mL	1.7604 mL	4.4010 mL
	30 mM	0.1467 mL	0.7335 mL	1.4670 mL	3.6675 mL
	40 mM	0.1100 mL	0.5501 mL	1.1003 mL	2.7506 mL
	50 mM	0.0880 mL	0.4401 mL	0.8802 mL	2.2005 mL
	60 mM	0.0734 mL	0.3668 mL	0.7335 mL	1.8338 mL
	80 mM	0.0550 mL	0.2751 mL	0.5501 mL	1.3753 mL
	100 mM	0.0440 mL	0.2201 mL	0.4401 mL	1.1003 mL