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  4. 3,6-Dihydroxyxanthone

3,6-Dihydroxyxanthone (compound 3) is a xanthone derivatives. 3,6-Dihydroxyxanthone (compound 3) has anticancer activity. 3,6-Dihydroxyxanthone (compound 3) can be used for cancer research.

For research use only. We do not sell to patients.

3,6-Dihydroxyxanthone Chemical Structure

3,6-Dihydroxyxanthone Chemical Structure

CAS No. : 1214-24-0

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Customer Review

Based on 1 publication(s) in Google Scholar

3,6-Dihydroxyxanthone Related Antibodies

Top Publications Citing Use of Products

  • Biological Activity

  • Purity & Documentation

  • References

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Description

3,6-Dihydroxyxanthone (compound 3) is a xanthone derivatives. 3,6-Dihydroxyxanthone (compound 3) has anticancer activity. 3,6-Dihydroxyxanthone (compound 3) can be used for cancer research[1].

Cellular Effect
Cell Line Type Value Description References
BGC-823 IC50
12.9 μM
Compound: Table S1, R271C2
Cytotoxicity against human BGC823 cells after 48 hrs by MTT assay
Cytotoxicity against human BGC823 cells after 48 hrs by MTT assay
[PMID: 30684866]
COLO 320 IC50
37.7 μM
Compound: 45370
Antiproliferative activity against human COLO320 cells after 48 hrs by CCK8 assay
Antiproliferative activity against human COLO320 cells after 48 hrs by CCK8 assay
[PMID: 28376372]
HepG2 IC50
61.7 μM
Compound: 45370
Antiproliferative activity against human HepG2 cells after 48 hrs by CCK8 assay
Antiproliferative activity against human HepG2 cells after 48 hrs by CCK8 assay
[PMID: 28376372]
K562 IC50
31.2 μM
Compound: 45370
Antiproliferative activity against human K562 cells after 48 hrs by CCK8 assay
Antiproliferative activity against human K562 cells after 48 hrs by CCK8 assay
[PMID: 28376372]
MCF7 IC50
91.3 μM
Compound: 45370
Antiproliferative activity against human MCF7 cells after 48 hrs by CCK8 assay
Antiproliferative activity against human MCF7 cells after 48 hrs by CCK8 assay
[PMID: 28376372]
MDA-MB-231 IC50
31.7 μM
Compound: 45370
Antiproliferative activity against human MDA-MB-231 cells after 48 hrs by CCK8 assay
Antiproliferative activity against human MDA-MB-231 cells after 48 hrs by CCK8 assay
[PMID: 28376372]
In Vitro

3,6-Dihydroxyxanthone (compound 3) (3.906-1000 µg/mL; 24 hours) exhibits cytotoxic activity against WiDR and Vero cell lines with IC50 values of 785.58 and 1280.9 µM[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

3,6-Dihydroxyxanthone Related Antibodies

Cell Cytotoxicity Assay[1]

Cell Line: WiDR and Vero cell lines
Concentration: 3.906, 7.813, 15.625, 31.25, 62.5, 125, 250 and 500 µg/mL (WiDR cell line) 7.813, 15.625, 31.25, 62.5, 125, 250, 500 and 1000 µg/mL (Vero cell line)
Incubation Time: 24 hours
Result: Inhibited cell activity and with IC50 values of 785.58 and 1,280.9 µM for WiDR and Vero cell lines.
Molecular Weight

228.20

Formula

C13H8O4
CAS No.
Appearance

Solid

Color

White to yellow

SMILES

O=C1C2=C(OC3=C1C=CC(O)=C3)C=C(O)C=C2
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

4°C, stored under nitrogen

*In solvent : -80°C, 6 months; -20°C, 1 month (stored under nitrogen)

Solvent & Solubility
In Vitro: 

DMSO : 50 mg/mL (219.11 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 4.3821 mL 21.9106 mL 43.8212 mL
5 mM 0.8764 mL 4.3821 mL 8.7642 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (stored under nitrogen). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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This equation is commonly abbreviated as: C1V1 = C2V2

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In Vivo Dissolution Calculator
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Calculation results:
Working solution concentration: mg/mL
Purity & Documentation

Purity: 99.55%

SDS (393 KB)

COA (247 KB) HNMR (117 KB) RP-HPLC (201 KB)

Handling Instructions (2659 KB)
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (stored under nitrogen). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 4.3821 mL 21.9106 mL 43.8212 mL 109.5530 mL
5 mM 0.8764 mL 4.3821 mL 8.7642 mL 21.9106 mL
10 mM 0.4382 mL 2.1911 mL 4.3821 mL 10.9553 mL
15 mM 0.2921 mL 1.4607 mL 2.9214 mL 7.3035 mL
20 mM 0.2191 mL 1.0955 mL 2.1911 mL 5.4777 mL
25 mM 0.1753 mL 0.8764 mL 1.7528 mL 4.3821 mL
30 mM 0.1461 mL 0.7304 mL 1.4607 mL 3.6518 mL
40 mM 0.1096 mL 0.5478 mL 1.0955 mL 2.7388 mL
50 mM 0.0876 mL 0.4382 mL 0.8764 mL 2.1911 mL
60 mM 0.0730 mL 0.3652 mL 0.7304 mL 1.8259 mL
80 mM 0.0548 mL 0.2739 mL 0.5478 mL 1.3694 mL
100 mM 0.0438 mL 0.2191 mL 0.4382 mL 1.0955 mL
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3,6-Dihydroxyxanthone Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

3,6-Dihydroxyxanthone1214-24-0Othersxanthone derivativesanticancerInhibitorinhibitorinhibit

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