3,7-Dihydroxyflavone  (Synonyms: Resogalangin)

3,7-Dihydroxyflavone (Resogalangin) is a flavonoid phytoestrogen, which can be isolated from Adenophora species. 3,7-Dihydroxyflavone is a modulator of estrogen receptors and an inhibitor of human progesterone metabolizing enzyme AKR1C1 and fungal 17β-hydroxysteroid dehydrogenase and a redox inhibitor (IC₅₀=0.6 and 6.0 μM, respectively). 3,7-Dihydroxyflavone is a fluorescent binding substrate for human serum albumin (HSA) with excitation wavelengths of 370 nm (pH 7.4) and 350 nm (pH 3.5), respectively, and emission wavelength of 515 nm^[1][2].

For fluorescence assay with 3,7-Dihydroxyflavone and HSA, a stock solution of 3,7-Dihydroxyflavone was prepared in methanol with a final methanol concentration of less than 4% (v/v). Note that the pH of the phosphate buffer solution was adjusted to 3.5 and 7.4 with NaOH or H₃PO₄ solutions. The ionic strength of the solution was maintained at 0.1 M using NaCl solution. The experimental temperature was 25°C^[1].
Isopentenyl derivatives of 3,7-Dihydroxyflavone can inhibit tumor cell growth and proliferation and induce apoptosis^[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

254.24

C₁₅H₁₀O₄

492-00-2

O=C1C(O)=C(C2=CC=CC=C2)OC3=CC(O)=CC=C13

Room temperature in continental US; may vary elsewhere.

Please store the product under the recommended conditions in the Certificate of Analysis.

• [1]. Ma J, et al. Spectroscopic investigation on the interaction of 3,7-dihydroxyflavone with different isomers of human serum albumin. Food Chem. 2012 May 1;132(1):663-70.  [Content Brief]

  [2]. Neves MP, et al. Prenylated derivatives of baicalein and 3,7-dihydroxyflavone: synthesis and study of their effects on tumor cell lines growth, cell cycle and apoptosis. Eur J Med Chem. 2011 Jun;46(6):2562-74.  [Content Brief]