2. Cell Cycle/DNA Damage
  3. Nucleoside Antimetabolite/Analog
  4. 3'-Azido-3'-deoxyadenosine

3'-Azido-3'-deoxyadenosine is a purine nucleoside analogue. Purine nucleoside analogs have broad antitumor activity targeting indolent lymphoid malignancies. Anticancer mechanisms in this process rely on inhibition of DNA synthesis, induction of apoptosis, etc. 3'-Azido-3'-deoxyadenosine is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.

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3'-Azido-3'-deoxyadenosine Chemical Structure

3'-Azido-3'-deoxyadenosine Chemical Structure

CAS No. : 58699-62-0

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3'-Azido-3'-deoxyadenosine Related Antibodies

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Description

3'-Azido-3'-deoxyadenosine is a purine nucleoside analogue. Purine nucleoside analogs have broad antitumor activity targeting indolent lymphoid malignancies. Anticancer mechanisms in this process rely on inhibition of DNA synthesis, induction of apoptosis, etc[1]. 3'-Azido-3'-deoxyadenosine is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.

Molecular Weight

292.25

Formula

C10H12N8O3
CAS No.
Appearance

Solid

Color

White to off-white

SMILES

OC[C@H]1O[C@@H](N(C=N2)C3=C2C(N)=NC=N3)[C@H](O)[C@@H]1N=[N+]=[N-]
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 125 mg/mL (427.72 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 3.4217 mL 17.1086 mL 34.2173 mL
5 mM 0.6843 mL 3.4217 mL 6.8435 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 3.4217 mL 17.1086 mL 34.2173 mL 85.5432 mL
5 mM 0.6843 mL 3.4217 mL 6.8435 mL 17.1086 mL
10 mM 0.3422 mL 1.7109 mL 3.4217 mL 8.5543 mL
15 mM 0.2281 mL 1.1406 mL 2.2812 mL 5.7029 mL
20 mM 0.1711 mL 0.8554 mL 1.7109 mL 4.2772 mL
25 mM 0.1369 mL 0.6843 mL 1.3687 mL 3.4217 mL
30 mM 0.1141 mL 0.5703 mL 1.1406 mL 2.8514 mL
40 mM 0.0855 mL 0.4277 mL 0.8554 mL 2.1386 mL
50 mM 0.0684 mL 0.3422 mL 0.6843 mL 1.7109 mL
60 mM 0.0570 mL 0.2851 mL 0.5703 mL 1.4257 mL
80 mM 0.0428 mL 0.2139 mL 0.4277 mL 1.0693 mL
100 mM 0.0342 mL 0.1711 mL 0.3422 mL 0.8554 mL
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3'-Azido-3'-deoxyadenosine Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

3'-Azido-3'-deoxyadenosine58699-62-0Nucleoside Antimetabolite/Analogindolent lymphoid malignanciesantitumorInhibitorinhibitorinhibit

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