3-Methyl-GABA

Name: 3-Methyl-GABA
Brand: MedChemExpress
SKU: HY-115685
Rating: 4.5 (1 reviews)

Cat. No.: HY-115685 Purity: 99.86%: FAQs
Data Sheet SDS COA Handling Instructions

Molarity Calculator

3-Methyl-GABA is a potent GABA aminotransferase activator. 3-Methyl-GABA can fit the binding pocket of GABA_A receptor (GABAaR). 3-Methyl-GABA can activate L-glutamic acid decarboxylase (GAD). 3-Methyl-GABA has anticonvulsant activity.

For research use only. We do not sell to patients.

3-Methyl-GABA Chemical Structure

CAS No. : 1216629-00-3

Size	Price	Stock	Quantity
Solid + Solvent (Highly Recommended)
10 mM * 1 mL in DMSO ready for reconstitution	USD 242	In-stock	Estimated Time of Arrival: December 31
Solution
10 mM * 1 mL in DMSO	USD 242	In-stock	Estimated Time of Arrival: December 31
Solid
5 mg	USD 220	In-stock	Estimated Time of Arrival: December 31
10 mg	USD 360	In-stock	Estimated Time of Arrival: December 31
50 mg		Get quote
100 mg		Get quote

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Based on 1 publication(s) in Google Scholar

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Description

In Vitro

The GAD activation is stereoselective for the R isomer of 3-methyl GABA relative to the corresponding S isomer^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

522.59

Formula

C₂₀H₃₀N₂O₁₀S₂

CAS No.

1216629-00-3

Appearance

Solid

Color

White to light brown

SMILES

O=S(C1=C2C=CC=C(S(=O)(O)=O)C2=CC=C1)(O)=O.O=C(O)CC(C)CN.O=C(O)CC(C)CN

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Powder	-20°C	3 years
	4°C	2 years
In solvent	-80°C	6 months
	-20°C	1 month

Solvent & Solubility

In Vitro:

DMSO : 125 mg/mL (239.19 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	1.9135 mL	9.5677 mL	19.1355 mL
5 mM	0.3827 mL	1.9135 mL	3.8271 mL
10 mM	0.1914 mL	0.9568 mL	1.9135 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Concentration _(start)

Volume _(start)

Concentration _(final)

Volume _(final)

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

Dosage

mg/kg

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(per animal)

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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Calculation results:

Working solution concentration: mg/mL

Purity & Documentation

Purity: 99.86%

Select Batch:

Data Sheet (276 KB) SDS (251 KB)

COA (253 KB) HNMR (265 KB) LCMS (90 KB)

Handling Instructions (2659 KB)

References

[1]. R B Silverman, et al. 3-Alkyl-4-aminobutyric acids: the first class of anticonvulsant agents that activates L-glutamic acid decarboxylase. J Med Chem. 1991 Jul;34(7):2295-8. [Content Brief]

[2]. Z. YANG, et al. MOLECULAR INTERACTIONS OF GABA ANALOGUES AGAINST THE α+β-INTERFACE OF GABAARECEPTOR: DOCKING AND MOLECULAR DYNAMICS STUDIES. Digest Journal of Nanomaterials and Biostructures, Vol. 10, No. 3, July -September 2015.

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

DMSO	1 mM	1.9135 mL	9.5677 mL	19.1355 mL	47.8386 mL
	5 mM	0.3827 mL	1.9135 mL	3.8271 mL	9.5677 mL
	10 mM	0.1914 mL	0.9568 mL	1.9135 mL	4.7839 mL
	15 mM	0.1276 mL	0.6378 mL	1.2757 mL	3.1892 mL
	20 mM	0.0957 mL	0.4784 mL	0.9568 mL	2.3919 mL
	25 mM	0.0765 mL	0.3827 mL	0.7654 mL	1.9135 mL
	30 mM	0.0638 mL	0.3189 mL	0.6378 mL	1.5946 mL
	40 mM	0.0478 mL	0.2392 mL	0.4784 mL	1.1960 mL
	50 mM	0.0383 mL	0.1914 mL	0.3827 mL	0.9568 mL
	60 mM	0.0319 mL	0.1595 mL	0.3189 mL	0.7973 mL
	80 mM	0.0239 mL	0.1196 mL	0.2392 mL	0.5980 mL
	100 mM	0.0191 mL	0.0957 mL	0.1914 mL	0.4784 mL

3-Methyl-GABA Related Classifications

Neurological Disease

Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

3-Methyl-GABA1216629-00-3GABA ReceptorGamma-aminobutyric acid Receptorγ-Aminobutyric acid ReceptorInhibitorinhibitorinhibit

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3-Methyl-GABA

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3-Methyl-GABA Related Antibodies

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3-Methyl-GABA Related Antibodies

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Complete Stock Solution Preparation Table

3-Methyl-GABA Related Classifications

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