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  3. Isotope-Labeled Compounds
  4. 3-Methyl-2-quinoxalinecarboxylic acid-d4

3-Methyl-2-quinoxalinecarboxylic acid-d4  (Synonyms: MQCA-d4)

Cat. No.: HY-W016099S Purity: 99.60%
SDS COA Handling Instructions

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3-Methyl-2-quinoxalinecarboxylic acid-d4 is the deuterium labeled 3-Methyl-2-quinoxalinecarboxylic acid. 3-Methyl-2-quinoxalinecarboxylic acid (MQCA), an important N-oxide reductive metabolite of Quinocetone or Olaquindox, potently inhibits the growth of Chang liver cells through S phase arrest of the cell cycle[1].

For research use only. We do not sell to patients.

3-Methyl-2-quinoxalinecarboxylic acid-d<sub>4</sub> Chemical Structure

3-Methyl-2-quinoxalinecarboxylic acid-d4 Chemical Structure

CAS No. : 2244217-93-2

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1 mg USD 300 In-stock
5 mg USD 760 In-stock
10 mg USD 1230 In-stock
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Based on 1 publication(s) in Google Scholar

Other Forms of 3-Methyl-2-quinoxalinecarboxylic acid-d4:

3-Methyl-2-quinoxalinecarboxylic acid-d4 Related Antibodies

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Description

3-Methyl-2-quinoxalinecarboxylic acid-d4 is the deuterium labeled 3-Methyl-2-quinoxalinecarboxylic acid. 3-Methyl-2-quinoxalinecarboxylic acid (MQCA), an important N-oxide reductive metabolite of Quinocetone or Olaquindox, potently inhibits the growth of Chang liver cells through S phase arrest of the cell cycle[1].

In Vitro

Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

3-Methyl-2-quinoxalinecarboxylic acid-d4 Related Antibodies
Molecular Weight

192.21

Formula

C10H4D4N2O2
CAS No.
Appearance

Solid

Color

Off-white to light brown

SMILES

O=C(C1=NC2=C([2H])C([2H])=C([2H])C([2H])=C2N=C1C)O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : ≥ 30 mg/mL (156.08 mM; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

DMSO : ≥ 30 mg/mL (156.08 mM; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Ethanol : ≥ 25 mg/mL (130.07 mM)

DMF : ≥ 25 mg/mL (130.07 mM)

DMF : ≥ 25 mg/mL (130.07 mM)

Ethanol : ≥ 25 mg/mL (130.07 mM)

DMSO:PBS (pH 7.2) (1:10) : ≥ 0.1 mg/mL (0.52 mM)

*"≥" means soluble, but saturation unknown.

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 5.2026 mL 26.0132 mL 52.0264 mL
5 mM 1.0405 mL 5.2026 mL 10.4053 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
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Volume
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Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

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Volume (start)

V1

=
Concentration (final)

C2

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Volume (final)

V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation

Purity: 99.60%

SDS (252 KB)

COA (250 KB)

Handling Instructions (2659 KB)
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
Ethanol / DMF / DMF / Ethanol / DMSO / DMSO 1 mM 5.2026 mL 26.0132 mL 52.0264 mL 130.0661 mL
5 mM 1.0405 mL 5.2026 mL 10.4053 mL 26.0132 mL
10 mM 0.5203 mL 2.6013 mL 5.2026 mL 13.0066 mL
15 mM 0.3468 mL 1.7342 mL 3.4684 mL 8.6711 mL
20 mM 0.2601 mL 1.3007 mL 2.6013 mL 6.5033 mL
25 mM 0.2081 mL 1.0405 mL 2.0811 mL 5.2026 mL
30 mM 0.1734 mL 0.8671 mL 1.7342 mL 4.3355 mL
40 mM 0.1301 mL 0.6503 mL 1.3007 mL 3.2517 mL
50 mM 0.1041 mL 0.5203 mL 1.0405 mL 2.6013 mL
60 mM 0.0867 mL 0.4336 mL 0.8671 mL 2.1678 mL
80 mM 0.0650 mL 0.3252 mL 0.6503 mL 1.6258 mL
100 mM 0.0520 mL 0.2601 mL 0.5203 mL 1.3007 mL
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3-Methyl-2-quinoxalinecarboxylic acid-d4 Related Classifications

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  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

3-Methyl-2-quinoxalinecarboxylic acid-d42244217-93-2MQCA-d4Isotope-Labeled CompoundsInhibitorinhibitorinhibit

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