2. Epigenetics Cell Cycle/DNA Damage MAPK/ERK Pathway Stem Cell/Wnt TGF-beta/Smad Cytoskeleton
  3. ROCK p38 MAPK PKC
  4. 3′-O-Demethyl-4′-N-demethyl-4′-N-acetyl-4′-epi-staurosporine

3′-O-Demethyl-4′-N-demethyl-4′-N-acetyl-4′-epi-staurosporine 

Cat. No.: HY-N12466
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3′-O-Demethyl-4′-N-demethyl-4′-N-acetyl-4′-epi-staurosporine (Compound 7) is an inhibitor of protein kinases, with IC50s of 0.092, 0.26, 0.77 μM for PKC-α, ROCK, ASK1. 3′-O-Demethyl-4′-N-demethyl-4′-N-acetyl-4′-epi-staurosporine shows potent cytotoxicity against PC-3 cancer cells with an IC50 value of 0.16 μM.

For research use only. We do not sell to patients.

3′-O-Demethyl-4′-N-demethyl-4′-N-acetyl-4′-epi-staurosporine Chemical Structure

3′-O-Demethyl-4′-N-demethyl-4′-N-acetyl-4′-epi-staurosporine Chemical Structure

CAS No. : 2226941-29-1

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3′-O-Demethyl-4′-N-demethyl-4′-N-acetyl-4′-epi-staurosporine Related Antibodies

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ROCK ROCK1 ROCK2

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p38 MAPK p38α p38β MAPK13 p38δ p38γ

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PKC PKCα PKCβ PKCγ PKCδ PKCε PKCη PKCζ PKCθ PKCμ PKC-ι ℩ PKCι

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Description

3′-O-Demethyl-4′-N-demethyl-4′-N-acetyl-4′-epi-staurosporine (Compound 7) is an inhibitor of protein kinases, with IC50s of 0.092, 0.26, 0.77 μM for PKC-α, ROCK, ASK1. 3′-O-Demethyl-4′-N-demethyl-4′-N-acetyl-4′-epi-staurosporine shows potent cytotoxicity against PC-3 cancer cells with an IC50 value of 0.16 μM[1].

Molecular Weight

480.51

Formula

C28H24N4O4
CAS No.
SMILES

O=C1C2=C3C(N4C5=C3C=CC=C5)=C6C(C(C=CC=C7)=C7N6[C@]8(C)[C@H](O)[C@@H](NC(C)=O)C[C@@]4([H])O8)=C2CN1
Structure Classification
Initial Source

Streptomyces sp
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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3′-O-Demethyl-4′-N-demethyl-4′-N-acetyl-4′-epi-staurosporine Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

3′-O-Demethyl-4′-N-demethyl-4′-N-acetyl-4′-epi-staurosporine2226941-29-1ROCKp38 MAPKPKCRho-associated protein kinaseRho-associated kinaseRho-kinaseROKProtein kinase CInhibitorinhibitorinhibit

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