2. Cell Cycle/DNA Damage
  3. Nucleoside Antimetabolite/Analog
  4. 3′-O-Methyladenosine

(2R,3R,4S,5R)-2-(6-amino-9H-purin-9-yl)-5-(hydroxymethyl)-4-methoxytetrahydrofuran-3-ol (Adenosine, 3'-O-methyl- (8CI)(9CI)) is an adenosine analogue. Adenosine analogs mostly act as smooth muscle vasodilators and have also been shown to inhibit cancer progression. The popular products in this series are adenosine phosphate, Acadesine (HY-13417), Clofarabine (HY-A0005), Fludarabine phosphate (HY-B0028) and Vidarabine (HY-B0277).

For research use only. We do not sell to patients.

3′-O-Methyladenosine Chemical Structure

3′-O-Methyladenosine Chemical Structure

CAS No. : 10300-22-8

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3′-O-Methyladenosine Related Antibodies

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Description

(2R,3R,4S,5R)-2-(6-amino-9H-purin-9-yl)-5-(hydroxymethyl)-4-methoxytetrahydrofuran-3-ol (Adenosine, 3'-O-methyl- (8CI)(9CI)) is an adenosine analogue. Adenosine analogs mostly act as smooth muscle vasodilators and have also been shown to inhibit cancer progression. The popular products in this series are adenosine phosphate, Acadesine (HY-13417), Clofarabine (HY-A0005), Fludarabine phosphate (HY-B0028) and Vidarabine (HY-B0277)[1].

Molecular Weight

281.27

Formula

C11H15N5O4
CAS No.
Appearance

Solid

Color

White to off-white

SMILES

O[C@@H]1[C@H](OC)[C@@H](CO)O[C@H]1N2C=NC3=C(N=CN=C32)N
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

4°C, protect from light

*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

Solvent & Solubility
In Vitro: 

DMSO : 100 mg/mL (355.53 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 3.5553 mL 17.7765 mL 35.5530 mL
5 mM 0.7111 mL 3.5553 mL 7.1106 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

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In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 3.5553 mL 17.7765 mL 35.5530 mL 88.8826 mL
5 mM 0.7111 mL 3.5553 mL 7.1106 mL 17.7765 mL
10 mM 0.3555 mL 1.7777 mL 3.5553 mL 8.8883 mL
15 mM 0.2370 mL 1.1851 mL 2.3702 mL 5.9255 mL
20 mM 0.1778 mL 0.8888 mL 1.7777 mL 4.4441 mL
25 mM 0.1422 mL 0.7111 mL 1.4221 mL 3.5553 mL
30 mM 0.1185 mL 0.5926 mL 1.1851 mL 2.9628 mL
40 mM 0.0889 mL 0.4444 mL 0.8888 mL 2.2221 mL
50 mM 0.0711 mL 0.3555 mL 0.7111 mL 1.7777 mL
60 mM 0.0593 mL 0.2963 mL 0.5926 mL 1.4814 mL
80 mM 0.0444 mL 0.2222 mL 0.4444 mL 1.1110 mL
100 mM 0.0356 mL 0.1778 mL 0.3555 mL 0.8888 mL
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3′-O-Methyladenosine Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

3′-O-Methyladenosine10300-22-8Nucleoside Antimetabolite/Analogmuscle vasodilatorInhibitorinhibitorinhibit

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