2. Stem Cell/Wnt
  3. Wnt
  4. 3289-8625

3289-8625 is an inhibitor of the PDZ domain of Dishevelled (Dvl) protein (Kd=10.6 μM) and has an inhibitory effect on Wnt signaling. In addition, 3289-8625 can slow the growth of prostate cancer PC-3 cells (IC50=12.5 μM). 3289-8625 can be used in the study of embryonic development and cancer.

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3289-8625 Chemical Structure

3289-8625 Chemical Structure

CAS No. : 294891-81-9

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10 mg USD 145 In-stock
25 mg USD 290 In-stock
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Description

3289-8625 is an inhibitor of the PDZ domain of Dishevelled (Dvl) protein (Kd=10.6 μM) and has an inhibitory effect on Wnt signaling. In addition, 3289-8625 can slow the growth of prostate cancer PC-3 cells (IC50=12.5 μM). 3289-8625 can be used in the study of embryonic development and cancer[1].

Molecular Weight

374.39

Formula

C22H18N2O4
CAS No.
Appearance

Solid

SMILES

O=C(O)C1=CC=CC=C1NC(C2=CC=CC(NC(CC3=CC=CC=C3)=O)=C2)=O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 125 mg/mL (333.88 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.6710 mL 13.3551 mL 26.7101 mL
5 mM 0.5342 mL 2.6710 mL 5.3420 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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This equation is commonly abbreviated as: C1V1 = C2V2

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In Vivo Dissolution Calculator
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Working solution concentration: mg/mL
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 2.6710 mL 13.3551 mL 26.7101 mL 66.7753 mL
5 mM 0.5342 mL 2.6710 mL 5.3420 mL 13.3551 mL
10 mM 0.2671 mL 1.3355 mL 2.6710 mL 6.6775 mL
15 mM 0.1781 mL 0.8903 mL 1.7807 mL 4.4517 mL
20 mM 0.1336 mL 0.6678 mL 1.3355 mL 3.3388 mL
25 mM 0.1068 mL 0.5342 mL 1.0684 mL 2.6710 mL
30 mM 0.0890 mL 0.4452 mL 0.8903 mL 2.2258 mL
40 mM 0.0668 mL 0.3339 mL 0.6678 mL 1.6694 mL
50 mM 0.0534 mL 0.2671 mL 0.5342 mL 1.3355 mL
60 mM 0.0445 mL 0.2226 mL 0.4452 mL 1.1129 mL
80 mM 0.0334 mL 0.1669 mL 0.3339 mL 0.8347 mL
100 mM 0.0267 mL 0.1336 mL 0.2671 mL 0.6678 mL
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3289-8625 Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

3289-8625294891-81-9WntPDZ domaininhibitorWNT signaling pathwayProstate cancer PC-3 cell lineInhibitorinhibit

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