2. MAPK/ERK Pathway
  3. MAP4K
  4. (3S,4R)-GNE-6893

(3S,4R)-GNE-6893 is a potent and orally active HPK1 inhibitor. (3S,4R)-GNE-6893 can be used in research of cancer.

For research use only. We do not sell to patients.

(3S,4R)-GNE-6893 Chemical Structure

(3S,4R)-GNE-6893 Chemical Structure

CAS No. : 2415374-97-7

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Based on 1 publication(s) in Google Scholar

Other Forms of (3S,4R)-GNE-6893:

(3S,4R)-GNE-6893 Related Antibodies

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MAP4K2/GCK MAP4K3/GLK MAP4K4/HGK MAP4K5/KHS1 MAP4K6/MINK1 MAP4K7/TNIK MAP4K1/HPK1

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Description

(3S,4R)-GNE-6893 is a potent and orally active HPK1 inhibitor. (3S,4R)-GNE-6893 can be used in research of cancer[1].

Molecular Weight

453.47

Formula

C23H24FN5O4
CAS No.
Appearance

Solid

Color

Off-white to light yellow

SMILES

FC1=C(N)C(C=NC(NC(O[C@H]2[C@@H](COC2)C)=O)=C3)=C3C=C1C4=CN=C(OCCN5)C5=C4C
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 100 mg/mL (220.52 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.2052 mL 11.0261 mL 22.0522 mL
5 mM 0.4410 mL 2.2052 mL 4.4104 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
×
Volume
×
Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

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Volume (start)

V1

=
Concentration (final)

C2

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Volume (final)

V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

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g

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 2.2052 mL 11.0261 mL 22.0522 mL 55.1304 mL
5 mM 0.4410 mL 2.2052 mL 4.4104 mL 11.0261 mL
10 mM 0.2205 mL 1.1026 mL 2.2052 mL 5.5130 mL
15 mM 0.1470 mL 0.7351 mL 1.4701 mL 3.6754 mL
20 mM 0.1103 mL 0.5513 mL 1.1026 mL 2.7565 mL
25 mM 0.0882 mL 0.4410 mL 0.8821 mL 2.2052 mL
30 mM 0.0735 mL 0.3675 mL 0.7351 mL 1.8377 mL
40 mM 0.0551 mL 0.2757 mL 0.5513 mL 1.3783 mL
50 mM 0.0441 mL 0.2205 mL 0.4410 mL 1.1026 mL
60 mM 0.0368 mL 0.1838 mL 0.3675 mL 0.9188 mL
80 mM 0.0276 mL 0.1378 mL 0.2757 mL 0.6891 mL
100 mM 0.0221 mL 0.1103 mL 0.2205 mL 0.5513 mL
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(3S,4R)-GNE-6893 Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

(3S,4R)-GNE-68932415374-97-7MAP4KMAPK Kinase Kinase KinaseInhibitorinhibitorinhibit

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