3α,21-Dihydroxy-5α-pregnan-20-one (Synonyms: THDOC)

Cat. No.: HY-123489 Purity: ≥98.0%: FAQs
Data Sheet SDS COA Handling Instructions

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3α,21-Dihydroxy-5α-pregnan-20-one (THDOC), an endogenous neurosteroid, is a positive modulator of GABA_A receptors. 3α,21-Dihydroxy-5α-pregnan-20-one potentiates neuronal response to low concentrations of GABA at α4β1δ GABA_A receptors in vitro.

For research use only. We do not sell to patients.

3α,21-Dihydroxy-5α-pregnan-20-one Chemical Structure

CAS No. : 567-02-2

Size	Price	Stock	Quantity
5 mg	USD 260	In-stock	Estimated Time of Arrival: December 31
10 mg	USD 420	In-stock	Estimated Time of Arrival: December 31
25 mg	USD 840	In-stock	Estimated Time of Arrival: December 31
50 mg	USD 1350	In-stock	Estimated Time of Arrival: December 31
100 mg	USD 2160	In-stock	Estimated Time of Arrival: December 31
200 mg		Get quote
500 mg		Get quote

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Based on 1 publication(s) in Google Scholar

Other Forms of 3α,21-Dihydroxy-5α-pregnan-20-one:

3α,21-Dihydroxy-5α-pregnan-20-one-d₃ Get quote

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Description

Molecular Weight

334.49

Formula

C₂₁H₃₄O₃

CAS No.

567-02-2

Appearance

Solid

Color

White to off-white

SMILES

C[C@@]12[C@H](CC[C@]1([C@@]3(CC[C@]4(C[C@@H](CC[C@@]4([C@]3(CC2)[H])C)O)[H])[H])[H])C(CO)=O

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Powder	-20°C	3 years
In solvent	-80°C	6 months
	-20°C	1 month

Solvent & Solubility

In Vitro:

DMSO : 100 mg/mL (298.96 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	2.9896 mL	14.9481 mL	29.8963 mL
5 mM	0.5979 mL	2.9896 mL	5.9793 mL
10 mM	0.2990 mL	1.4948 mL	2.9896 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Concentration _(start)

Volume _(start)

Concentration _(final)

Volume _(final)

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Calculation results:

Working solution concentration: mg/mL

Purity & Documentation

Purity: ≥98.0%

Select Batch:

Data Sheet (245 KB) SDS (420 KB)

COA (252 KB) HNMR (260 KB) MS (70 KB)

Handling Instructions (2659 KB)

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

DMSO	1 mM	2.9896 mL	14.9481 mL	29.8963 mL	74.7407 mL
	5 mM	0.5979 mL	2.9896 mL	5.9793 mL	14.9481 mL
	10 mM	0.2990 mL	1.4948 mL	2.9896 mL	7.4741 mL
	15 mM	0.1993 mL	0.9965 mL	1.9931 mL	4.9827 mL
	20 mM	0.1495 mL	0.7474 mL	1.4948 mL	3.7370 mL
	25 mM	0.1196 mL	0.5979 mL	1.1959 mL	2.9896 mL
	30 mM	0.0997 mL	0.4983 mL	0.9965 mL	2.4914 mL
	40 mM	0.0747 mL	0.3737 mL	0.7474 mL	1.8685 mL
	50 mM	0.0598 mL	0.2990 mL	0.5979 mL	1.4948 mL
	60 mM	0.0498 mL	0.2491 mL	0.4983 mL	1.2457 mL
	80 mM	0.0374 mL	0.1869 mL	0.3737 mL	0.9343 mL
	100 mM	0.0299 mL	0.1495 mL	0.2990 mL	0.7474 mL

3α,21-Dihydroxy-5α-pregnan-20-one Related Classifications

Neurological Disease

Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

3α,21-Dihydroxy-5α-pregnan-20-one567-02-2THDOCGABA ReceptorGamma-aminobutyric acid Receptorγ-Aminobutyric acid ReceptorInhibitorinhibitorinhibit

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3α,21-Dihydroxy-5α-pregnan-20-one (Synonyms: THDOC)

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Complete Stock Solution Preparation Table

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