2. Immunology/Inflammation
  3. COX
  4. 4,4'-Dihydroxy-2,6-dimethoxydihydrochalcone

4,4'-Dihydroxy-2,6-dimethoxydihydrochalcone 

Cat. No.: HY-N8184 Purity: 99.64%
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4,4'-Dihydroxy-2,6-dimethoxydihydrochalcone exhibits COX-1 and COX-2 inhibitory activity.

For research use only. We do not sell to patients.

4,4'-Dihydroxy-2,6-dimethoxydihydrochalcone Chemical Structure

4,4'-Dihydroxy-2,6-dimethoxydihydrochalcone Chemical Structure

CAS No. : 151752-08-8

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1 mg USD 75 In-stock
5 mg USD 180 In-stock
10 mg USD 290 In-stock
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Based on 1 publication(s) in Google Scholar

4,4'-Dihydroxy-2,6-dimethoxydihydrochalcone Related Antibodies

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Description

4,4'-Dihydroxy-2,6-dimethoxydihydrochalcone exhibits COX-1 and COX-2 inhibitory activity[1].

IC50 & Target[1]

COX-1

 

COX-2

 

Molecular Weight

302.32

Formula

C17H18O5
CAS No.
Appearance

Solid

Color

White to off-white

SMILES

O=C(C1=CC=C(O)C=C1)CCC2=C(OC)C=C(O)C=C2OC
Structure Classification
Initial Source
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

4°C, sealed storage, away from moisture and light

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)

Solvent & Solubility
In Vitro: 

DMSO : 25 mg/mL (82.69 mM; Need ultrasonic and warming; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 3.3078 mL 16.5388 mL 33.0775 mL
5 mM 0.6616 mL 3.3078 mL 6.6155 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
×
Volume
×
Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

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Volume (start)

V1

=
Concentration (final)

C2

×
Volume (final)

V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 3.3078 mL 16.5388 mL 33.0775 mL 82.6938 mL
5 mM 0.6616 mL 3.3078 mL 6.6155 mL 16.5388 mL
10 mM 0.3308 mL 1.6539 mL 3.3078 mL 8.2694 mL
15 mM 0.2205 mL 1.1026 mL 2.2052 mL 5.5129 mL
20 mM 0.1654 mL 0.8269 mL 1.6539 mL 4.1347 mL
25 mM 0.1323 mL 0.6616 mL 1.3231 mL 3.3078 mL
30 mM 0.1103 mL 0.5513 mL 1.1026 mL 2.7565 mL
40 mM 0.0827 mL 0.4135 mL 0.8269 mL 2.0673 mL
50 mM 0.0662 mL 0.3308 mL 0.6616 mL 1.6539 mL
60 mM 0.0551 mL 0.2756 mL 0.5513 mL 1.3782 mL
80 mM 0.0413 mL 0.2067 mL 0.4135 mL 1.0337 mL
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4,4'-Dihydroxy-2,6-dimethoxydihydrochalcone Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

4,4'-Dihydroxy-2,6-dimethoxydihydrochalcone151752-08-8COXCyclooxygenaseInhibitorinhibitorinhibit

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