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  4. 4-(Chloromethyl)-7-hydroxycoumarin

4-(Chloromethyl)-7-hydroxycoumarin 

Cat. No.: HY-76779 Purity: 97.96%
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4-(Chloromethyl)-7-hydroxycoumarin (compound 4) is a hydroxycoumarin derivative with potent antioxidant effect and high hydroxyl radical-scavenging property. 4-(Chloromethyl)-7-hydroxycoumarin contains a methyl group and a chlorine group in the heterocyclic ring. A series of coumarins incorporating hydroxy-, chloro- and/or chloromethyl-moieties has been investigated as potent inhibitors of the zinc enzyme carbonic anhydrase, expecially tumor-associated isoforms CA IX and XII.

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4-(Chloromethyl)-7-hydroxycoumarin Chemical Structure

4-(Chloromethyl)-7-hydroxycoumarin Chemical Structure

CAS No. : 25392-41-0

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250 mg USD 54 In-stock
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4-(Chloromethyl)-7-hydroxycoumarin Related Antibodies

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Description

4-(Chloromethyl)-7-hydroxycoumarin (compound 4) is a hydroxycoumarin derivative with potent antioxidant effect and high hydroxyl radical-scavenging property. 4-(Chloromethyl)-7-hydroxycoumarin contains a methyl group and a chlorine group in the heterocyclic ring. A series of coumarins incorporating hydroxy-, chloro- and/or chloromethyl-moieties has been investigated as potent inhibitors of the zinc enzyme carbonic anhydrase, expecially tumor-associated isoforms CA IX and XII[1][2].

Molecular Weight

210.61

Formula

C10H7ClO3
CAS No.
Appearance

Solid

Color

Off-white to pink

SMILES

O=C1OC(C=C2O)=C(C=C2)C(CCl)=C1
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

4°C, stored under nitrogen

*In solvent : -80°C, 6 months; -20°C, 1 month (stored under nitrogen)

Solvent & Solubility
In Vitro: 

DMSO : ≥ 100 mg/mL (474.81 mM; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

*"≥" means soluble, but saturation unknown.

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 4.7481 mL 23.7406 mL 47.4811 mL
5 mM 0.9496 mL 4.7481 mL 9.4962 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (stored under nitrogen). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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=
Concentration
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Volume
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Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

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Volume (start)

V1

=
Concentration (final)

C2

×
Volume (final)

V2

In Vivo Dissolution Calculator
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Calculation results:
Working solution concentration: mg/mL
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (stored under nitrogen). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 4.7481 mL 23.7406 mL 47.4811 mL 118.7028 mL
5 mM 0.9496 mL 4.7481 mL 9.4962 mL 23.7406 mL
10 mM 0.4748 mL 2.3741 mL 4.7481 mL 11.8703 mL
15 mM 0.3165 mL 1.5827 mL 3.1654 mL 7.9135 mL
20 mM 0.2374 mL 1.1870 mL 2.3741 mL 5.9351 mL
25 mM 0.1899 mL 0.9496 mL 1.8992 mL 4.7481 mL
30 mM 0.1583 mL 0.7914 mL 1.5827 mL 3.9568 mL
40 mM 0.1187 mL 0.5935 mL 1.1870 mL 2.9676 mL
50 mM 0.0950 mL 0.4748 mL 0.9496 mL 2.3741 mL
60 mM 0.0791 mL 0.3957 mL 0.7914 mL 1.9784 mL
80 mM 0.0594 mL 0.2968 mL 0.5935 mL 1.4838 mL
100 mM 0.0475 mL 0.2374 mL 0.4748 mL 1.1870 mL
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4-(Chloromethyl)-7-hydroxycoumarin Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

4-(Chloromethyl)-7-hydroxycoumarin25392-41-0Othershydroxycoumarinchloromethyl-moietyantioxidant capacitybovine aortic endothelial cellsconfocal microscopycytoprotection assaysESRInhibitorinhibitorinhibit

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