4-Hydroperoxy Cyclophosphamide-d₄

Name: 4-Hydroperoxy Cyclophosphamide-d 4
Brand: MedChemExpress
SKU: HY-117433S
Rating: 4.5 (1 reviews)

Cat. No.: HY-117433S Purity: ≥95.0%: FAQs
Data Sheet SDS COA Handling Instructions

Molarity Calculator

4-Hydroperoxy Cyclophosphamide-d₄ is the deuterium labeled 4-Hydroperoxy cyclophosphamide. 4-Hydroperoxy cyclophosphamide is the active metabolite form of the proagent Cyclophosphamide. 4-Hydroperoxy cyclophosphamide crosslinks DNA and induces T cell apoptosis independent of death receptor activation, but activates mitochondrial death pathways through production of reactive oxygen species (ROS). 4-Hydroperoxy cyclophosphamide has the potential for lymphomas and autoimmune disorders[1][2].

For research use only. We do not sell to patients.

4-Hydroperoxy Cyclophosphamide-d<sub>4</sub> Chemical Structure

4-Hydroperoxy Cyclophosphamide-d₄ Chemical Structure

CAS No. : 1246816-71-6

Size	Price	Stock	Quantity
100 μg	USD 130	In-stock	Estimated Time of Arrival: December 31
1 mg	USD 650	In-stock	Estimated Time of Arrival: December 31
5 mg		Get quote
10 mg		Get quote

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Based on 1 publication(s) in Google Scholar

Other Forms of 4-Hydroperoxy Cyclophosphamide-d₄:

4-Hydroperoxy cyclophosphamide Get quote

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Biological Activity
Purity & Documentation
References
Customer Review

Description

In Vitro

Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

297.11

Formula

C₇H₁₁D₄Cl₂N₂O₄P

CAS No.

1246816-71-6

Unlabeled CAS

39800-16-3

Appearance

Solid

Color

Off-white to light yellow

SMILES

N(CC(Cl)([2H])[2H])(CC(Cl)([2H])[2H])P1(=O)NC(OO)CCO1

Shipping

Shipping with dry ice.

Storage

-80°C, stored under nitrogen

Solvent & Solubility

In Vitro:

DMSO : 50 mg/mL (168.29 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	3.3658 mL	16.8288 mL	33.6576 mL
5 mM	0.6732 mL	3.3658 mL	6.7315 mL
10 mM	0.3366 mL	1.6829 mL	3.3658 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months (stored under nitrogen). When stored at -80°C, please use it within 6 months.

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Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Concentration _(start)

Volume _(start)

Concentration _(final)

Volume _(final)

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Calculation results:

Working solution concentration: mg/mL

Purity & Documentation

Purity: ≥95.0%

Select Batch:

Data Sheet (277 KB) SDS (251 KB)

COA (255 KB) Elemental Analysis Report (114 KB)

Handling Instructions (2659 KB)

References

[1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53(2):211-216. [Content Brief]

[2]. 4-hydroperoxy-cyclophosphamide mediates caspase-independent T-cell apoptosis involving oxidative stress-induced nuclear relocation of mitochondrial apoptogenic factors AIF and EndoG [Content Brief]

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

DMSO / DMSO	1 mM	3.3658 mL	16.8288 mL	33.6576 mL	84.1439 mL
	5 mM	0.6732 mL	3.3658 mL	6.7315 mL	16.8288 mL
	10 mM	0.3366 mL	1.6829 mL	3.3658 mL	8.4144 mL
	15 mM	0.2244 mL	1.1219 mL	2.2438 mL	5.6096 mL
	20 mM	0.1683 mL	0.8414 mL	1.6829 mL	4.2072 mL
	25 mM	0.1346 mL	0.6732 mL	1.3463 mL	3.3658 mL
	30 mM	0.1122 mL	0.5610 mL	1.1219 mL	2.8048 mL
	40 mM	0.0841 mL	0.4207 mL	0.8414 mL	2.1036 mL
	50 mM	0.0673 mL	0.3366 mL	0.6732 mL	1.6829 mL
	60 mM	0.0561 mL	0.2805 mL	0.5610 mL	1.4024 mL
	80 mM	0.0421 mL	0.2104 mL	0.4207 mL	1.0518 mL
	100 mM	0.0337 mL	0.1683 mL	0.3366 mL	0.8414 mL