4-Hydroperoxyifosfamide

Name: 4-Hydroperoxyifosfamide
Brand: MedChemExpress
SKU: HY-134228
Rating: 4.5 (1 reviews)

Cat. No.: HY-134228 Purity: ≥98.0%: FAQs
Data Sheet SDS COA Handling Instructions

Molarity Calculator

4-Hydroperoxyifosfamide is an anticancer agent that can penetrate the blood-brain barrier (BBB).

For research use only. We do not sell to patients.

4-Hydroperoxyifosfamide Chemical Structure

CAS No. : 39800-28-7

Size	Price	Stock	Quantity
1 mg	USD 540	In-stock	Estimated Time of Arrival: December 31
5 mg	USD 1350	In-stock	Estimated Time of Arrival: December 31
10 mg	USD 2160	In-stock	Estimated Time of Arrival: December 31
25 mg	USD 4380	In-stock	Estimated Time of Arrival: December 31
50 mg	USD 5700	In-stock	Estimated Time of Arrival: December 31
100 mg		Get quote
200 mg		Get quote

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Biological Activity
Purity & Documentation
References
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Description

4-Hydroperoxyifosfamide is an anticancer agent that can penetrate the blood-brain barrier (BBB)^[1].

Molecular Weight

293.08

Formula

C₇H₁₅Cl₂N₂O₄P

CAS No.

39800-28-7

Appearance

Solid

Color

White to off-white

SMILES

OOC1N(CCCl)P(OCC1)(NCCCl)=O

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Powder	-20°C	3 years
In solvent	-80°C	6 months
	-20°C	1 month

Solvent & Solubility

In Vitro:

DMSO : ≥ 100 mg/mL (341.20 mM; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

H₂O : 5 mg/mL (17.06 mM; ultrasonic and warming and heat to 60°C)

*"≥" means soluble, but saturation unknown.

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	3.4120 mL	17.0602 mL	34.1204 mL
5 mM	0.6824 mL	3.4120 mL	6.8241 mL
10 mM	0.3412 mL	1.7060 mL	3.4120 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

Molarity Calculator
Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Concentration _(start)

Volume _(start)

Concentration _(final)

Volume _(final)

In Vivo:

Select the appropriate dissolution method based on your experimental animal and administration route.

For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for in vivo experiments, it is recommended to prepare freshly and use it on the same day.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

Protocol 1

Add each solvent one by one: 10% DMSO 40% PEG300 5% Tween-80 45% Saline
Solubility: ≥ 2.5 mg/mL (8.53 mM); Clear solution

This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown).
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 400 μL PEG300, and mix evenly; then add 50 μL Tween-80 and mix evenly; then add 450 μL Saline to adjust the volume to 1 mL.
Preparation of Saline: Dissolve 0.9 g sodium chloride in ddH₂O and dilute to 100 mL to obtain a clear Saline solution.
Protocol 2

Add each solvent one by one: 10% DMSO 90% (20% SBE-β-CD in Saline)
Solubility: ≥ 2.5 mg/mL (8.53 mM); Clear solution

This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown).
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 900 μL 20% SBE-β-CD in Saline, and mix evenly.
Preparation of 20% SBE-β-CD in Saline (4°C, storage for one week): 2 g SBE-β-CD powder is dissolved in 10 mL Saline, completely dissolve until clear.
Protocol 3

Add each solvent one by one: 10% DMSO 90% Corn Oil
Solubility: ≥ 2.5 mg/mL (8.53 mM); Clear solution

This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown). If the continuous dosing period exceeds half a month, please choose this protocol carefully.
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 900 μL Corn oil, and mix evenly.

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Please enter your animal formula composition:

DMSO +

Tween-80 +

Saline

Recommended: Keep the proportion of DMSO in working solution below 2% if your animal is weak.

The co-solvents required include: DMSO, . All of co-solvents are available by MedChemExpress (MCE). , Tween 80. All of co-solvents are available by MedChemExpress (MCE).

Calculation results:

Working solution concentration: mg/mL

Method for preparing stock solution: mg drug dissolved in μL DMSO (Stock solution concentration: mg/mL).

The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only. If necessary, please contact MedChemExpress (MCE).

Method for preparing in vivo working solution for animal experiments: Take μL DMSO stock solution, add μL . μL , mix evenly, next add μL Tween 80, mix evenly, then add μL Saline.

If the continuous dosing period exceeds half a month, please choose this protocol carefully.

Please ensure that the stock solution in the first step is dissolved to a clear state, and add co-solvents in sequence. You can use ultrasonic heating (ultrasonic cleaner, recommended frequency 20-40 kHz), vortexing, etc. to assist dissolution.

Purity & Documentation

Purity: ≥98.0%

Select Batch:

Data Sheet (273 KB) SDS (393 KB)

COA (251 KB) HNMR (254 KB) CNMR (259 KB)

Handling Instructions (2659 KB)

References

[1]. Ishimoto TM, et al. Allelic variants of the human glutathione S-transferase P1 gene confer differential cytoprotection against anticancer agents in Escherichia coli. Pharmacogenetics. 2002 Oct;12(7):543-53. [Content Brief]

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

H₂O / DMSO	1 mM	3.4120 mL	17.0602 mL	34.1204 mL	85.3009 mL
	5 mM	0.6824 mL	3.4120 mL	6.8241 mL	17.0602 mL
	10 mM	0.3412 mL	1.7060 mL	3.4120 mL	8.5301 mL
	15 mM	0.2275 mL	1.1373 mL	2.2747 mL	5.6867 mL
DMSO	20 mM	0.1706 mL	0.8530 mL	1.7060 mL	4.2650 mL
	25 mM	0.1365 mL	0.6824 mL	1.3648 mL	3.4120 mL
	30 mM	0.1137 mL	0.5687 mL	1.1373 mL	2.8434 mL
	40 mM	0.0853 mL	0.4265 mL	0.8530 mL	2.1325 mL
	50 mM	0.0682 mL	0.3412 mL	0.6824 mL	1.7060 mL
	60 mM	0.0569 mL	0.2843 mL	0.5687 mL	1.4217 mL
	80 mM	0.0427 mL	0.2133 mL	0.4265 mL	1.0663 mL
	100 mM	0.0341 mL	0.1706 mL	0.3412 mL	0.8530 mL

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.