4-Hydroxyoxyphenbutazone 

4-Hydroxyoxyphenbutazone kills both replicating and nonreplicating (NR) Mycobacterium tuberculosis (Mtb), including Mtb resistant to standard agents. 4-Hydroxyoxyphenbutazone is a potent inhibitor of cytokine production. 4-Hydroxyoxyphenbutazone is an immunosuppressive agent and has the potential for rheumatoid arthritis research^[1][2].

4-Hydroxyoxyphenbutazone kills R Mtb in liquid culture with an MIC of 100 μM in the presence of 0.5% BSA and an MIC of 25 μM at lower BSA concentrations. The bactericidal spectrum of 4-Hydroxyoxyphenbutazone is remarkably narrow, with weak activity against Mycobacterium smegmatis (MIC of 200 μM in 7H9 lacking BSA). 4-Hydroxyoxyphenbutazone was inactive on E. coli, S. enterica var^[1].
4-Hydroxyoxyphenbutazone efficiently inhibits both monokines and Th1 and Th2 lymphokines in peripheral mononuclear cells (PBMC)^[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

340.37

C₁₉H₂₀N₂O₄

55648-39-0

O=C1N(N(C(C1(CCCC)O)=O)C2=CC=C(C=C2)O)C3=CC=CC=C3

Room temperature in continental US; may vary elsewhere.

Please store the product under the recommended conditions in the Certificate of Analysis.

• [1]. Ben Gold, et al. Nonsteroidal anti-inflammatory drug sensitizes Mycobacterium tuberculosis to endogenous and exogenous antimicrobials.  [Content Brief]

  [2]. Anja Ten Brinke, et al. 4-Hydroxy-oxyphenbutazone is a potent inhibitor of cytokine production. Eur Cytokine Netw. 2005 Jun;16(2):144-51.  [Content Brief]