4'-Methoxyflavone

Cat. No.: HY-139054 Purity: 99.63%: FAQs
Data Sheet SDS COA Handling Instructions Technical Support

4'-Methoxyflavone is a flavonoid with antioxidant properties and anti-proliferative activity against cancer cells. 4'-Methoxyflavone can inhibit cycle-dependent kinases leading to cell cycle arrest and regulate cell signaling pathways to influence cell proliferation and apoptosis. 4'-Methoxyflavone can be used in cancer chemoprevention research.

For research use only. We do not sell to patients.

4'-Methoxyflavone Chemical Structure

CAS No. : 4143-74-2

Size	Stock	Quantity
10 mg	In-stock	Estimated Time of Arrival: December 31
25 mg	In-stock	Estimated Time of Arrival: December 31
50 mg	Get quote
100 mg	Get quote

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Customer Review

Based on 1 publication(s) in Google Scholar

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Biological Activity
Purity & Documentation
References
Customer Review

Description

Cellular Effect

Cell Line	Type	Value	Description	References
BTI-TN-5B1-4	IC₅₀	27.87 μM Compound: 3d	Inhibition of human recombinant MAOB expressed in BTI-TN-5B1-4 cells by para-tyramine oxidation assay Inhibition of human recombinant MAOB expressed in BTI-TN-5B1-4 cells by para-tyramine oxidation assay	[PMID: 20045650]
MCF7	GI₅₀	61.8 μM Compound: 1e	Cytotoxicity against Homo sapiens (human) MCF7 cells after 48 hr by SRB assay Cytotoxicity against Homo sapiens (human) MCF7 cells after 48 hr by SRB assay	10.1007/s00044-012-0423-1
MDCK	CC₅₀	191.8 μM Compound: 1f	Cytotoxicity against dog MDCK cells assessed as reduction in cell viability by MTT assay Cytotoxicity against dog MDCK cells assessed as reduction in cell viability by MTT assay	[PMID: 31744778]
MDCK	EC₅₀	9.36 nM Compound: 1f	Antiviral activity against Influenza A virus (H1N1) infected in dog MDCK cells assessed as reduction in log2HA titer incubated for 3 to 4 days by CPE assay Antiviral activity against Influenza A virus (H1N1) infected in dog MDCK cells assessed as reduction in log2HA titer incubated for 3 to 4 days by CPE assay	[PMID: 31744778]
MOLT-4	GI₅₀	99.2 μM Compound: 1e	Cytotoxicity against Homo sapiens (human) MOLT4 cells after 48 hr by SRB assay Cytotoxicity against Homo sapiens (human) MOLT4 cells after 48 hr by SRB assay	10.1007/s00044-012-0423-1

Molecular Weight

252.26

Formula

C₁₆H₁₂O₃

CAS No.

4143-74-2

Appearance

Solid

Color

White to off-white

SMILES

O=C1C=C(C2=CC=C(OC)C=C2)OC3=CC=CC=C13

Structure Classification

Initial Source

Endogenous metabolite

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Powder	-20°C	3 years
	4°C	2 years
In solvent	-80°C	6 months
	-20°C	1 month

Solvent & Solubility

In Vitro:

DMSO : 10 mg/mL (39.64 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	3.9642 mL	19.8208 mL	39.6416 mL
5 mM	0.7928 mL	3.9642 mL	7.9283 mL
10 mM	0.3964 mL	1.9821 mL	3.9642 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Molarity Calculator
Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Concentration _(start)

Volume _(start)

Concentration _(final)

Volume _(final)

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

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mg/kg

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(per animal)

μL

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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Calculation results:

Working solution concentration: mg/mL

Purity & Documentation

Purity: 99.63%

Select Batch:

Data Sheet (268 KB) SDS (392 KB)

COA (247 KB) HNMR (225 KB) LCMS (98 KB)

Handling Instructions (2659 KB)

References

[1]. Walle U K, et al. Bioavailable flavonoids: cytochrome P450-mediated metabolism of methoxyflavones[J]. Drug Metabolism and Disposition, 2007, 35(11): 1985-1989. [Content Brief]

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

DMSO	1 mM	3.9642 mL	19.8208 mL	39.6416 mL	99.1041 mL
	5 mM	0.7928 mL	3.9642 mL	7.9283 mL	19.8208 mL
	10 mM	0.3964 mL	1.9821 mL	3.9642 mL	9.9104 mL
	15 mM	0.2643 mL	1.3214 mL	2.6428 mL	6.6069 mL
	20 mM	0.1982 mL	0.9910 mL	1.9821 mL	4.9552 mL
	25 mM	0.1586 mL	0.7928 mL	1.5857 mL	3.9642 mL
	30 mM	0.1321 mL	0.6607 mL	1.3214 mL	3.3035 mL