2. Vitamin D Related/Nuclear Receptor
  3. Nuclear Hormone Receptor 4A/NR4A
  4. 4A7C-301

4A7C-301 is a Nurr1 agonist with robust neuroprotective effects in vitro. 4A7C-301 significantly ameliorates neuropathological abnormalities and improves motor and olfactory dysfunctions in AAV2-mediated α-synuclein-overexpressing male mouse models. 4A7C-301 can be used for the research of Parkinson’s disease.

For research use only. We do not sell to patients.

4A7C-301 Chemical Structure

4A7C-301 Chemical Structure

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500 μg USD 65 In-stock
1 mg USD 98 In-stock
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Based on 1 publication(s) in Google Scholar

4A7C-301 Related Antibodies

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View All Nuclear Hormone Receptor 4A/NR4A Isoform Specific Products:

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Nurr1/NR4A2 Nur77/NR4A1

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Description

4A7C-301 is a Nurr1 agonist with robust neuroprotective effects in vitro. 4A7C-301 significantly ameliorates neuropathological abnormalities and improves motor and olfactory dysfunctions in AAV2-mediated α-synuclein-overexpressing male mouse models. 4A7C-301 can be used for the research of Parkinson’s disease[1].

IC50 & Target

Nurr1/NR4A2

 

Molecular Weight

524.10

Formula

C27H38ClN9
Appearance

Solid

SMILES

ClC1=CC=C2C(NCCNC3=NC(N4CCN(CC)CC4)=CC(N5CCN(CC)CC5)=N3)=CC=NC2=C1
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 20 mg/mL (38.16 mM; Need ultrasonic and warming; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 1.9080 mL 9.5402 mL 19.0803 mL
5 mM 0.3816 mL 1.9080 mL 3.8161 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
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Concentration
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Volume
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Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

×
Volume (start)

V1

=
Concentration (final)

C2

×
Volume (final)

V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

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(per animal)

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Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation

Purity: 98.8%

COA (251 KB)

Handling Instructions (2659 KB)
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 1.9080 mL 9.5402 mL 19.0803 mL 47.7008 mL
5 mM 0.3816 mL 1.9080 mL 3.8161 mL 9.5402 mL
10 mM 0.1908 mL 0.9540 mL 1.9080 mL 4.7701 mL
15 mM 0.1272 mL 0.6360 mL 1.2720 mL 3.1801 mL
20 mM 0.0954 mL 0.4770 mL 0.9540 mL 2.3850 mL
25 mM 0.0763 mL 0.3816 mL 0.7632 mL 1.9080 mL
30 mM 0.0636 mL 0.3180 mL 0.6360 mL 1.5900 mL
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4A7C-301 Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

4A7C-301Nuclear Hormone Receptor 4A/NR4ANerve Growth Factor IB-like ReceptorNurr1neuroprotectiveAAV2-mediated α-synuclein-overexpressing male mouse modelsParkinson’s diseaseInhibitorinhibitorinhibit

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