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  4. 4α-TPA

4α-TPA is an inactive form of TPA, and is used as a negative control for TPA-activated events.

For research use only. We do not sell to patients.

4α-TPA Chemical Structure

4α-TPA Chemical Structure

CAS No. : 63597-44-4

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Based on 1 publication(s) in Google Scholar

4α-TPA Related Antibodies

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  • Biological Activity

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Description

4α-TPA is an inactive form of TPA, and is used as a negative control for TPA-activated events[1].

Cellular Effect
Cell Line Type Value Description References
MT4 EC50
> 17 μM
Compound: 14, 4alpha-TPA
Antiviral activity against HIV2 ROD infected in MT4 cells assessed as cell viability after 5 days by MTT assay
Antiviral activity against HIV2 ROD infected in MT4 cells assessed as cell viability after 5 days by MTT assay
[PMID: 25970561]
MT4 EC50
> 18 μM
Compound: 14, 4alpha-TPA
Antiviral activity against HIV1 3B infected in MT4 cells assessed as cell viability after 5 days by MTT assay
Antiviral activity against HIV1 3B infected in MT4 cells assessed as cell viability after 5 days by MTT assay
[PMID: 25970561]
Vero EC50
2.8 μM
Compound: 5, 4alpha-TPA
Antiviral activity against Chikungunya virus 899 infected in african green monkey Vero cells assessed as inhibition of virus-induced cytopathic effect incubated for 6 to 7 days by MTS assay
Antiviral activity against Chikungunya virus 899 infected in african green monkey Vero cells assessed as inhibition of virus-induced cytopathic effect incubated for 6 to 7 days by MTS assay
[PMID: 23215460]
Vero EC50
2.8 μM
Compound: 14, 4alpha-TPA
Antiviral activity against chikungunya virus Indian ocean strain 899 infected in Vero cells assessed as virus-induced cytopathic effect after 6 to 7 days
Antiviral activity against chikungunya virus Indian ocean strain 899 infected in Vero cells assessed as virus-induced cytopathic effect after 6 to 7 days
[PMID: 25970561]
Vero CC50
5.3 μM
Compound: 5, 4alpha-TPA
Cytotoxicity against african green monkey Vero cells by MTS assay
Cytotoxicity against african green monkey Vero cells by MTS assay
[PMID: 23215460]
In Vitro

TPA (5, 50, and 100 ng/ml; 24 hours), but not 4α-TPA, induces MMP-9 enzyme activity (MMP-9 zym) and mRNA expression (MMP-9 mRNA) in U87 cells[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

4α-TPA Related Antibodies
Molecular Weight

616.83

Formula

C36H56O8
CAS No.
SMILES

CC(O[C@@]12[C@@]([C@@]3([H])[C@]([C@@H]([C@H]2OC(CCCCCCCCCCCCC)=O)C)([C@@]4([H])[C@@](CC(CO)=C3)(C(C(C)=C4)=O)O)O)([H])C1(C)C)=O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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4α-TPA Related Classifications

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The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

4α-TPA63597-44-4α-TPAOthersnegativecontrolTPAactivationeventsInhibitorinhibitorinhibit

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HY-106029
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