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  5. 5,​7,​3'-​Trihydroxy-​6,​4',​5'-​trimethoxyflavone

5,​7,​3'-​Trihydroxy-​6,​4',​5'-​trimethoxyflavone 

Cat. No.: HY-N6259 Purity: 99.82%
COA Handling Instructions

Molarity Calculator

5,7,3'-Trihydroxy-6,4',5'-trimethoxyflavone is a methylated flavones from Artemisia frigida.

For research use only. We do not sell to patients.

5,​7,​3'-​Trihydroxy-​6,​4',​5'-​trimethoxyflavone Chemical Structure

5,​7,​3'-​Trihydroxy-​6,​4',​5'-​trimethoxyflavone Chemical Structure

CAS No. : 78417-26-2

Size Price Stock Quantity
5 mg USD 300 In-stock
10 mg USD 465 In-stock
25 mg USD 820 In-stock
50 mg USD 1200 In-stock
100 mg   Get quote  
200 mg   Get quote  

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This product is a controlled substance and not for sale in your territory.

Customer Review

Based on 1 publication(s) in Google Scholar

Other Forms of 5,​7,​3'-​Trihydroxy-​6,​4',​5'-​trimethoxyflavone:

5,​7,​3'-​Trihydroxy-​6,​4',​5'-​trimethoxyflavone Related Antibodies

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  • Biological Activity

  • Purity & Documentation

  • References

  • Customer Review

Description

5,7,3'-Trihydroxy-6,4',5'-trimethoxyflavone is a methylated flavones from Artemisia frigida.

Molecular Weight

360.31

Formula

C18H16O8
CAS No.
Appearance

Solid

Color

Off-white to light yellow

SMILES

OC1=C2C(OC(C3=CC(OC)=C(OC)C(O)=C3)=CC2=O)=CC(O)=C1OC
Structure Classification
Initial Source
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

-20°C, sealed storage, away from moisture and light

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)

Solvent & Solubility
In Vitro: 

DMSO : 100 mg/mL (277.54 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.7754 mL 13.8769 mL 27.7539 mL
5 mM 0.5551 mL 2.7754 mL 5.5508 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
×
Volume
×
Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

×
Volume (start)

V1

=
Concentration (final)

C2

×
Volume (final)

V2

In Vivo:

Select the appropriate dissolution method based on your experimental animal and administration route.

For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for in vivo experiments, it is recommended to prepare freshly and use it on the same day.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

  • Protocol 1

    Add each solvent one by one:  10% DMSO    90% (20% SBE-β-CD in Saline)

    Solubility: ≥ 2.5 mg/mL (6.94 mM); Clear solution

    This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown).

    Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 900 μL 20% SBE-β-CD in Saline, and mix evenly.

    Preparation of 20% SBE-β-CD in Saline (4°C, storage for one week): 2 g SBE-β-CD powder is dissolved in 10 mL Saline, completely dissolve until clear.
In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

g

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Please enter your animal formula composition:
%
DMSO +
% 
+
%
Tween-80 +
%
Saline
Recommended: Keep the proportion of DMSO in working solution below 2% if your animal is weak.
The co-solvents required include: DMSO, . All of co-solvents are available by MedChemExpress (MCE). , Tween 80. All of co-solvents are available by MedChemExpress (MCE).
Calculation results:
Working solution concentration: mg/mL
Method for preparing stock solution: mg drug dissolved in μL  DMSO (Stock solution concentration: mg/mL).

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)

The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only. If necessary, please contact MedChemExpress (MCE).
Method for preparing in vivo working solution for animal experiments: Take μL DMSO stock solution, add μL . μL , mix evenly, next add μL Tween 80, mix evenly, then add μL Saline.
 If the continuous dosing period exceeds half a month, please choose this protocol carefully.
Please ensure that the stock solution in the first step is dissolved to a clear state, and add co-solvents in sequence. You can use ultrasonic heating (ultrasonic cleaner, recommended frequency 20-40 kHz), vortexing, etc. to assist dissolution.
Purity & Documentation

Purity: 99.82%

COA (252 KB) HNMR (254 KB) LCMS (95 KB)

Handling Instructions (2659 KB)
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 2.7754 mL 13.8769 mL 27.7539 mL 69.3847 mL
5 mM 0.5551 mL 2.7754 mL 5.5508 mL 13.8769 mL
10 mM 0.2775 mL 1.3877 mL 2.7754 mL 6.9385 mL
15 mM 0.1850 mL 0.9251 mL 1.8503 mL 4.6256 mL
20 mM 0.1388 mL 0.6938 mL 1.3877 mL 3.4692 mL
25 mM 0.1110 mL 0.5551 mL 1.1102 mL 2.7754 mL
30 mM 0.0925 mL 0.4626 mL 0.9251 mL 2.3128 mL
40 mM 0.0694 mL 0.3469 mL 0.6938 mL 1.7346 mL
50 mM 0.0555 mL 0.2775 mL 0.5551 mL 1.3877 mL
60 mM 0.0463 mL 0.2313 mL 0.4626 mL 1.1564 mL
80 mM 0.0347 mL 0.1735 mL 0.3469 mL 0.8673 mL
100 mM 0.0278 mL 0.1388 mL 0.2775 mL 0.6938 mL
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5,​7,​3'-​Trihydroxy-​6,​4',​5'-​trimethoxyflavone Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

5,​7,​3'-​Trihydroxy-​6,​4',​5'-​trimethoxyflavone78417-26-2OthersInhibitorinhibitorinhibit

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