2. Metabolic Enzyme/Protease
  3. Endogenous Metabolite
  4. 5-Amino-3H-imidazole-4-Carboxamide

5-Amino-3H-imidazole-4-Carboxamide  (Synonyms: 5-Aminoimidazole-4-carboxamide; AICA)

Cat. No.: HY-41461 Purity: 99.99%
SDS COA Handling Instructions Technical Support

5-Amino-3H-imidazole-4-Carboxamide (AICA) is an important precursor for the synthesis of purines in general and of the nucleobases adenine and guanine in particular.

For research use only. We do not sell to patients.

5-Amino-3H-imidazole-4-Carboxamide Chemical Structure

5-Amino-3H-imidazole-4-Carboxamide Chemical Structure

CAS No. : 360-97-4

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Solid + Solvent (Highly Recommended)
10 mM * 1 mL in DMSO
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Based on 1 publication(s) in Google Scholar

Other Forms of 5-Amino-3H-imidazole-4-Carboxamide:

5-Amino-3H-imidazole-4-Carboxamide Related Antibodies

Top Publications Citing Use of Products

1 Publications Citing Use of MCE 5-Amino-3H-imidazole-4-Carboxamide

  • Biological Activity

  • Purity & Documentation

  • References

  • Customer Review

Description

5-Amino-3H-imidazole-4-Carboxamide (AICA) is an important precursor for the synthesis of purines in general and of the nucleobases adenine and guanine in particular[1][2][3].

Molecular Weight

126.12

Formula

C4H6N4O
CAS No.
Appearance

Solid

Color

Off-white to gray

SMILES

O=C(C1=C(N)NC=N1)N
Structure Classification
Initial Source
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

4°C, protect from light

*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

Solvent & Solubility
In Vitro: 

DMSO : 100 mg/mL (792.90 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

H2O : 20 mg/mL (158.58 mM; Need ultrasonic)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 7.9290 mL 39.6451 mL 79.2902 mL
5 mM 1.5858 mL 7.9290 mL 15.8580 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
×
Volume
×
Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

×
Volume (start)

V1

=
Concentration (final)

C2

×
Volume (final)

V2

In Vivo:

For the following dissolution methods, please prepare the working solution directly. It is recommended to prepare fresh solutions and use them promptly within a short period of time.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

  • Protocol 1

    Add each solvent one by one:  PBS

    Solubility: 15 mg/mL (118.94 mM); Clear solution; Need ultrasonic

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

g

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
This product has good water solubility, please refer to the measured solubility data in water/PBS/Saline for details.
The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only.If necessary, please contact MedChemExpress (MCE).
Purity & Documentation

Purity: 99.99%

SDS (393 KB)

COA (252 KB) HNMR (119 KB) LCMS (243 KB)

Handling Instructions (2659 KB)
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
H2O / DMSO 1 mM 7.9290 mL 39.6451 mL 79.2902 mL 198.2255 mL
5 mM 1.5858 mL 7.9290 mL 15.8580 mL 39.6451 mL
10 mM 0.7929 mL 3.9645 mL 7.9290 mL 19.8225 mL
15 mM 0.5286 mL 2.6430 mL 5.2860 mL 13.2150 mL
20 mM 0.3965 mL 1.9823 mL 3.9645 mL 9.9113 mL
25 mM 0.3172 mL 1.5858 mL 3.1716 mL 7.9290 mL
30 mM 0.2643 mL 1.3215 mL 2.6430 mL 6.6075 mL
40 mM 0.1982 mL 0.9911 mL 1.9823 mL 4.9556 mL
50 mM 0.1586 mL 0.7929 mL 1.5858 mL 3.9645 mL
60 mM 0.1322 mL 0.6608 mL 1.3215 mL 3.3038 mL
80 mM 0.0991 mL 0.4956 mL 0.9911 mL 2.4778 mL
100 mM 0.0793 mL 0.3965 mL 0.7929 mL 1.9823 mL

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

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5-Amino-3H-imidazole-4-Carboxamide Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

5-Amino-3H-imidazole-4-Carboxamide360-97-45-Aminoimidazole-4-carboxamide AICAEndogenous MetaboliteInhibitorinhibitorinhibit

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