2. Apoptosis Autophagy Metabolic Enzyme/Protease
  3. Apoptosis Autophagy Mitophagy Endogenous Metabolite
  4. 5-Aminolevulinic acid-13C-1 hydrochloride

5-Aminolevulinic acid-13C-1 hydrochloride  (Synonyms: 5-ALA-13C-1 hydrochloride; δ-Aminolevulinic acid-13C-1 hydrochloride; 5-Amino-4-oxopentanoic acid-13C-1 hydrochloride)

Cat. No.: HY-N0305S3 Purity: ≥98.0%
COA Handling Instructions

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5-Aminolevulinic acid-13C-1 (5-ALA-13C-1) hydrochloride is the 13C labeled 5-Aminolevulinic acid hydrochloride. 5-Aminolevulinic acid hydrochloride (5-ALA hydrochloride) is an intermediate in heme biosynthesis in the body and the universal precursor of tetrapyrroles.

For research use only. We do not sell to patients.

5-Aminolevulinic acid-<sup>13</sup>C-1 hydrochloride Chemical Structure

5-Aminolevulinic acid-13C-1 hydrochloride Chemical Structure

CAS No. : 129720-94-1

Size Price Stock Quantity
1 mg USD 180 In-stock
5 mg USD 450 In-stock
10 mg USD 720 In-stock
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100 mg   Get quote  

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Based on 1 publication(s) in Google Scholar

Other Forms of 5-Aminolevulinic acid-13C-1 hydrochloride:

5-Aminolevulinic acid-13C-1 hydrochloride Related Antibodies

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  • Purity & Documentation

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Description

5-Aminolevulinic acid-13C-1 (5-ALA-13C-1) hydrochloride is the 13C labeled 5-Aminolevulinic acid hydrochloride[1]. 5-Aminolevulinic acid hydrochloride (5-ALA hydrochloride) is an intermediate in heme biosynthesis in the body and the universal precursor of tetrapyrroles[2][3].

In Vitro

Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

5-Aminolevulinic acid-13C-1 hydrochloride Related Antibodies
Molecular Weight

168.58

Formula

C413CH10ClNO3
CAS No.
Unlabeled CAS

5451-09-2
Appearance

Solid

Color

White to off-white

SMILES

OC(CC[13C](CN)=O)=O.Cl
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 100 mg/mL (593.19 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

DMSO : 50 mg/mL (296.60 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

H2O : 16.67 mg/mL (98.88 mM; ultrasonic and warming and heat to 60°C)

H2O : 16.67 mg/mL (98.88 mM; ultrasonic and warming and heat to 60°C)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 5.9319 mL 29.6595 mL 59.3190 mL
5 mM 1.1864 mL 5.9319 mL 11.8638 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
×
Volume
×
Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

×
Volume (start)

V1

=
Concentration (final)

C2

×
Volume (final)

V2

In Vivo:

Select the appropriate dissolution method based on your experimental animal and administration route.

For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for in vivo experiments, it is recommended to prepare freshly and use it on the same day.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

  • Protocol 1

    Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% Saline

    Solubility: ≥ 1.25 mg/mL (7.41 mM); Clear solution

    This protocol yields a clear solution of ≥ 1.25 mg/mL (saturation unknown).

    Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (12.5 mg/mL) to 400 μL PEG300, and mix evenly; then add 50 μL Tween-80 and mix evenly; then add 450 μL Saline to adjust the volume to 1 mL.

    Preparation of Saline: Dissolve 0.9 g sodium chloride in ddH₂O and dilute to 100 mL to obtain a clear Saline solution.
  • Protocol 2

    Add each solvent one by one:  10% DMSO    90% (20% SBE-β-CD in Saline)

    Solubility: ≥ 1.25 mg/mL (7.41 mM); Clear solution

    This protocol yields a clear solution of ≥ 1.25 mg/mL (saturation unknown).

    Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (12.5 mg/mL) to 900 μL 20% SBE-β-CD in Saline, and mix evenly.

    Preparation of 20% SBE-β-CD in Saline (4°C, storage for one week): 2 g SBE-β-CD powder is dissolved in 10 mL Saline, completely dissolve until clear.
In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

g

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
This product has good water solubility, please refer to the measured solubility data in water/PBS/Saline for details.
The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only.If necessary, please contact MedChemExpress (MCE).
Purity & Documentation

Purity: ≥98.0%

COA (244 KB)

Handling Instructions (2659 KB)
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
H2O / H2O / DMSO / DMSO 1 mM 5.9319 mL 29.6595 mL 59.3190 mL 148.2975 mL
5 mM 1.1864 mL 5.9319 mL 11.8638 mL 29.6595 mL
10 mM 0.5932 mL 2.9660 mL 5.9319 mL 14.8298 mL
15 mM 0.3955 mL 1.9773 mL 3.9546 mL 9.8865 mL
20 mM 0.2966 mL 1.4830 mL 2.9660 mL 7.4149 mL
25 mM 0.2373 mL 1.1864 mL 2.3728 mL 5.9319 mL
30 mM 0.1977 mL 0.9887 mL 1.9773 mL 4.9433 mL
40 mM 0.1483 mL 0.7415 mL 1.4830 mL 3.7074 mL
50 mM 0.1186 mL 0.5932 mL 1.1864 mL 2.9660 mL
60 mM 0.0989 mL 0.4943 mL 0.9887 mL 2.4716 mL
80 mM 0.0741 mL 0.3707 mL 0.7415 mL 1.8537 mL
DMSO / DMSO 100 mM 0.0593 mL 0.2966 mL 0.5932 mL 1.4830 mL

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

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5-Aminolevulinic acid-13C-1 hydrochloride Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

5-Aminolevulinic acid-13C-1129720-94-15-ALA-13C-1δ-Aminolevulinic acid-13C-15-Amino-4-oxopentanoic acid-13C-1ApoptosisAutophagyMitophagyEndogenous MetaboliteMitochondrial AutophagyInhibitorinhibitorinhibit

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