2. Metabolic Enzyme/Protease
  3. Drug Metabolite
  4. 5-Carboxy-2′-deoxyuridine

5-Carboxy-2′-deoxyuridine is a metabolite of Trifluridine. 5-Carboxy-2′-deoxyuridine is a methyl oxidation product of Thymidine that can be formed by menadione-mediated photosensitization of Thymidine.

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5-Carboxy-2′-deoxyuridine Chemical Structure

5-Carboxy-2′-deoxyuridine Chemical Structure

CAS No. : 14599-46-3

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5 mg USD 275 In-stock
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Based on 1 publication(s) in Google Scholar

Other Forms of 5-Carboxy-2′-deoxyuridine:

5-Carboxy-2′-deoxyuridine Related Antibodies

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Description

5-Carboxy-2′-deoxyuridine is a metabolite of Trifluridine[1]. 5-Carboxy-2′-deoxyuridine is a methyl oxidation product of Thymidine that can be formed by menadione-mediated photosensitization of Thymidine[2].

Molecular Weight

272.21

Formula

C10H12N2O7
CAS No.
Appearance

Solid

Color

White to off-white

SMILES

O[C@H]1C[C@H](N2C(NC(C(C(O)=O)=C2)=O)=O)O[C@@H]1CO
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 125 mg/mL (459.20 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 3.6736 mL 18.3682 mL 36.7363 mL
5 mM 0.7347 mL 3.6736 mL 7.3473 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

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In Vivo Dissolution Calculator
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Working solution concentration: mg/mL
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 3.6736 mL 18.3682 mL 36.7363 mL 91.8409 mL
5 mM 0.7347 mL 3.6736 mL 7.3473 mL 18.3682 mL
10 mM 0.3674 mL 1.8368 mL 3.6736 mL 9.1841 mL
15 mM 0.2449 mL 1.2245 mL 2.4491 mL 6.1227 mL
20 mM 0.1837 mL 0.9184 mL 1.8368 mL 4.5920 mL
25 mM 0.1469 mL 0.7347 mL 1.4695 mL 3.6736 mL
30 mM 0.1225 mL 0.6123 mL 1.2245 mL 3.0614 mL
40 mM 0.0918 mL 0.4592 mL 0.9184 mL 2.2960 mL
50 mM 0.0735 mL 0.3674 mL 0.7347 mL 1.8368 mL
60 mM 0.0612 mL 0.3061 mL 0.6123 mL 1.5307 mL
80 mM 0.0459 mL 0.2296 mL 0.4592 mL 1.1480 mL
100 mM 0.0367 mL 0.1837 mL 0.3674 mL 0.9184 mL
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5-Carboxy-2′-deoxyuridine Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

5-Carboxy-2′-deoxyuridine14599-46-3Drug Metabolitemetabolite of TrifluridineThymidinemethyl oxidation productInhibitorinhibitorinhibit

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