2. Apoptosis Cell Cycle/DNA Damage Anti-infection Metabolic Enzyme/Protease
  3. Apoptosis Nucleoside Antimetabolite/Analog HIV Endogenous Metabolite
  4. 5-Fluorouracil-13C,15N2

5-Fluorouracil-13C,15N2  (Synonyms: 5-FU-13C,15N2)

Cat. No.: HY-90006S1 Purity: ≥97.0%
COA Handling Instructions

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5-Fluorouracil-13C,15N2 is the 13C and 15N labeled 5-Fluorouracil[1]. 5-Fluorouracil (5-FU) is an analogue of uracil and a potent antitumor agent. 5-Fluorouracil affects pyrimidine synthesis by inhibiting thymidylate synthetase thus depleting intracellular dTTP pools. 5-Fluorouracil induces apoptosis and can be used as a chemical sensitizer[2][3]. 5-Fluorouracil also inhibits HIV[4].

For research use only. We do not sell to patients.

5-Fluorouracil-<sup>13</sup>C,<sup>15</sup>N<sub>2</sub> Chemical Structure

5-Fluorouracil-13C,15N2 Chemical Structure

CAS No. : 1189423-58-2

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Based on 1 publication(s) in Google Scholar

Other Forms of 5-Fluorouracil-13C,15N2:

5-Fluorouracil-13C,15N2 Related Antibodies

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Description

5-Fluorouracil-13C,15N2 is the 13C and 15N labeled 5-Fluorouracil[1]. 5-Fluorouracil (5-FU) is an analogue of uracil and a potent antitumor agent. 5-Fluorouracil affects pyrimidine synthesis by inhibiting thymidylate synthetase thus depleting intracellular dTTP pools. 5-Fluorouracil induces apoptosis and can be used as a chemical sensitizer[2][3]. 5-Fluorouracil also inhibits HIV[4].

In Vitro

Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

5-Fluorouracil-13C,15N2 Related Antibodies
Molecular Weight

133.06

Formula

C313CH3F15N2O2
CAS No.
Unlabeled CAS

51-21-8
Appearance

Solid

Color

White to off-white

SMILES

O=C1C(F)=C[15NH][13C]([15NH]1)=O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

H2O : 16.67 mg/mL (125.28 mM; ultrasonic and warming and heat to 60°C)

H2O : 16.67 mg/mL (125.28 mM; ultrasonic and warming and heat to 60°C)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 7.5154 mL 37.5770 mL 75.1541 mL
5 mM 1.5031 mL 7.5154 mL 15.0308 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

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  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
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Concentration
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Volume
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Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

×
Volume (start)

V1

=
Concentration (final)

C2

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Volume (final)

V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
This product has good water solubility, please refer to the measured solubility data in water/PBS/Saline for details.
The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only.If necessary, please contact MedChemExpress (MCE).
Purity & Documentation

Purity: ≥97.0%

COA (255 KB)

Handling Instructions (2659 KB)
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
H2O / H2O 1 mM 7.5154 mL 37.5770 mL 75.1541 mL 187.8852 mL
5 mM 1.5031 mL 7.5154 mL 15.0308 mL 37.5770 mL
10 mM 0.7515 mL 3.7577 mL 7.5154 mL 18.7885 mL
15 mM 0.5010 mL 2.5051 mL 5.0103 mL 12.5257 mL
20 mM 0.3758 mL 1.8789 mL 3.7577 mL 9.3943 mL
25 mM 0.3006 mL 1.5031 mL 3.0062 mL 7.5154 mL
30 mM 0.2505 mL 1.2526 mL 2.5051 mL 6.2628 mL
40 mM 0.1879 mL 0.9394 mL 1.8789 mL 4.6971 mL
50 mM 0.1503 mL 0.7515 mL 1.5031 mL 3.7577 mL
60 mM 0.1253 mL 0.6263 mL 1.2526 mL 3.1314 mL
80 mM 0.0939 mL 0.4697 mL 0.9394 mL 2.3486 mL
100 mM 0.0752 mL 0.3758 mL 0.7515 mL 1.8789 mL

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

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5-Fluorouracil-13C,15N2 Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

5-Fluorouracil-13C,15N21189423-58-25-FU-13C,15N2ApoptosisNucleoside Antimetabolite/AnalogHIVEndogenous MetaboliteHuman immunodeficiency virusInhibitorinhibitorinhibit

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