2. Cell Cycle/DNA Damage Epigenetics
  3. Sirtuin
  4. 5-Heptadecylresorcinol

5-Heptadecylresorcinol  (Synonyms: 5-n-Heptadecylresorcinol; AR-C17)

Cat. No.: HY-N2673 Purity: 99.83%
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5-Heptadecylresorcinol (AR-C17), a phenolic lipid component, is also an orally active mitochondrial protector. 5-Heptadecylresorcinol improves mitochondrial function via sirtuin3 signaling pathway, thus alleviates endothelial cell damage and apoptosis. 5-Heptadecylresorcinol induces sirtuin3-mediated autophagy. 5-Heptadecylresorcinol reduces the atherosclerotic plaques in the aortic root region of mice heart. 5-Heptadecylresorcinol can be used for research of atherosclerosis prevention and obesity.

For research use only. We do not sell to patients.

5-Heptadecylresorcinol Chemical Structure

5-Heptadecylresorcinol Chemical Structure

CAS No. : 41442-57-3

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Based on 1 publication(s) in Google Scholar

5-Heptadecylresorcinol Related Antibodies

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Description

5-Heptadecylresorcinol (AR-C17), a phenolic lipid component, is also an orally active mitochondrial protector. 5-Heptadecylresorcinol improves mitochondrial function via sirtuin3 signaling pathway, thus alleviates endothelial cell damage and apoptosis. 5-Heptadecylresorcinol induces sirtuin3-mediated autophagy. 5-Heptadecylresorcinol reduces the atherosclerotic plaques in the aortic root region of mice heart. 5-Heptadecylresorcinol can be used for research of atherosclerosis prevention and obesity[1][2].

IC50 & Target[1][2]

SIRT3

 

Cellular Effect
Cell Line Type Value Description References
HCT-116 IC50
18.94 μg/mL
Compound: 1
Growth inhibition of human HCT116 cells after 48 hrs by MTT assay
Growth inhibition of human HCT116 cells after 48 hrs by MTT assay
[PMID: 21658963]
HT-29 IC50
31.15 μg/mL
Compound: 1
Growth inhibition of human HT-29 cells after 48 hrs by MTT assay
Growth inhibition of human HT-29 cells after 48 hrs by MTT assay
[PMID: 21658963]
In Vitro

5-Heptadecylresorcinol (0, 0.5, 1, and 2 µM; 24 h) alleviates mitochondrial dysfunction through upregulation of SIRT3 in HUVECs[1].
5-Heptadecylresorcinol alleviates inflammatory conditioned medium (CM) induced adipocyte lipolysis and mitochondrial damage, accompanied by attenuated mitochondrial reactive oxygen species production and mitochondrial membrane depolarization[2].
5-Heptadecylresorcinol (5, 10 and 15 μM; 24 h) significantly prevents CM-induced adipocyte lipolysis by decreasing the release of glycerol in 3T3-L1 adipocytes[2].
5-Heptadecylresorcinol (5, 10 and 15 μM; 24 h) ameliorates mitochondrial dysfunction in adipocytes induced by CM[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

5-Heptadecylresorcinol Related Antibodies

Western Blot Analysis[2]

Cell Line: 3T3-L1 adipocytes
Concentration: 5, 10 and 15 μM
Incubation Time: 24 hours
Result: Increased the expression of UCP1, COX IV, PGC-1α, DRP1 and MFN2 proteins.
In Vivo

5-Heptadecylresorcinol (30 mg/kg, 150 mg/kg; po daily for 16 weeks) improves the lipid metabolism in HFD-fed ApoE−/− mice[1].
5-Heptadecylresorcinol (30 mg/kg, 150 mg/kg; po daily for 16 weeks) increases the body weight of mouse, and alleviates adipose tissue macrophage infiltration and mitochondrial dysfunction[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: C57BL/6J mice[1][2]
Dosage: 30 mg/kg, 150 mg/kg
Administration: PO; daily for 16 weeks
Result: Lowered serum total cholesterol, triglyceride, VLDL-C, and LDL-C levels[1].
Reduced adipose tissue macrophage infiltration from high-fat diet induced obese C57BL/6J mice[2].
Molecular Weight

348.56

Formula

C23H40O2
CAS No.
Appearance

Solid

Color

Off-white to light yellow

SMILES

OC1=CC(CCCCCCCCCCCCCCCCC)=CC(O)=C1
Structure Classification
Initial Source
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 100 mg/mL (286.89 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.8689 mL 14.3447 mL 28.6895 mL
5 mM 0.5738 mL 2.8689 mL 5.7379 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
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Volume
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Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

×
Volume (start)

V1

=
Concentration (final)

C2

×
Volume (final)

V2

In Vivo:

Select the appropriate dissolution method based on your experimental animal and administration route.

For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for in vivo experiments, it is recommended to prepare freshly and use it on the same day.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

  • Protocol 1

    Add each solvent one by one:  10% DMSO    90% (20% SBE-β-CD in Saline)

    Solubility: ≥ 2.5 mg/mL (7.17 mM); Clear solution

    This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown).

    Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 900 μL 20% SBE-β-CD in Saline, and mix evenly.

    Preparation of 20% SBE-β-CD in Saline (4°C, storage for one week): 2 g SBE-β-CD powder is dissolved in 10 mL Saline, completely dissolve until clear.
In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

g

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Please enter your animal formula composition:
%
DMSO +
% 
+
%
Tween-80 +
%
Saline
Recommended: Keep the proportion of DMSO in working solution below 2% if your animal is weak.
The co-solvents required include: DMSO, . All of co-solvents are available by MedChemExpress (MCE). , Tween 80. All of co-solvents are available by MedChemExpress (MCE).
Calculation results:
Working solution concentration: mg/mL
Method for preparing stock solution: mg drug dissolved in μL  DMSO (Stock solution concentration: mg/mL).
The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only. If necessary, please contact MedChemExpress (MCE).
Method for preparing in vivo working solution for animal experiments: Take μL DMSO stock solution, add μL . μL , mix evenly, next add μL Tween 80, mix evenly, then add μL Saline.
 If the continuous dosing period exceeds half a month, please choose this protocol carefully.
Please ensure that the stock solution in the first step is dissolved to a clear state, and add co-solvents in sequence. You can use ultrasonic heating (ultrasonic cleaner, recommended frequency 20-40 kHz), vortexing, etc. to assist dissolution.
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 2.8689 mL 14.3447 mL 28.6895 mL 71.7237 mL
5 mM 0.5738 mL 2.8689 mL 5.7379 mL 14.3447 mL
10 mM 0.2869 mL 1.4345 mL 2.8689 mL 7.1724 mL
15 mM 0.1913 mL 0.9563 mL 1.9126 mL 4.7816 mL
20 mM 0.1434 mL 0.7172 mL 1.4345 mL 3.5862 mL
25 mM 0.1148 mL 0.5738 mL 1.1476 mL 2.8689 mL
30 mM 0.0956 mL 0.4782 mL 0.9563 mL 2.3908 mL
40 mM 0.0717 mL 0.3586 mL 0.7172 mL 1.7931 mL
50 mM 0.0574 mL 0.2869 mL 0.5738 mL 1.4345 mL
60 mM 0.0478 mL 0.2391 mL 0.4782 mL 1.1954 mL
80 mM 0.0359 mL 0.1793 mL 0.3586 mL 0.8965 mL
100 mM 0.0287 mL 0.1434 mL 0.2869 mL 0.7172 mL
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5-Heptadecylresorcinol Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

5-Heptadecylresorcinol41442-57-35-n-Heptadecylresorcinol AR-C17SirtuinInhibitorinhibitorinhibit

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