2. Cell Cycle/DNA Damage
  3. Nucleoside Antimetabolite/Analog
  4. 5-Methyl-2-thiouridine

5-Methyl-2-thiouridine  (Synonyms: 2-Thio-5-methyluridine)

Cat. No.: HY-W394293 Purity: 99.53%
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5-Methyl-2-thiouridine (2-Thio-5-methyluridine) is a purine nucleoside analogue. Purine nucleoside analogs have broad antitumor activity targeting indolent lymphoid malignancies. Anticancer mechanisms in this process rely on inhibition of DNA synthesis, induction of apoptosis, etc.

For research use only. We do not sell to patients.

5-Methyl-2-thiouridine Chemical Structure

5-Methyl-2-thiouridine Chemical Structure

CAS No. : 32738-09-3

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5 mg USD 69 In-stock
10 mg USD 110 In-stock
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Based on 1 publication(s) in Google Scholar

5-Methyl-2-thiouridine Related Antibodies

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Description

5-Methyl-2-thiouridine (2-Thio-5-methyluridine) is a purine nucleoside analogue. Purine nucleoside analogs have broad antitumor activity targeting indolent lymphoid malignancies. Anticancer mechanisms in this process rely on inhibition of DNA synthesis, induction of apoptosis, etc[1].

Molecular Weight

274.29

Formula

C10H14N2O5S
CAS No.
Appearance

Solid

Color

White to off-white

SMILES

OC[C@@H]1[C@@H](O)[C@@H](O)[C@H](N2C(NC(C(C)=C2)=O)=S)O1
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Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 250 mg/mL (911.44 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 3.6458 mL 18.2289 mL 36.4578 mL
5 mM 0.7292 mL 3.6458 mL 7.2916 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
×
Volume
×
Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

×
Volume (start)

V1

=
Concentration (final)

C2

×
Volume (final)

V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

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g

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 3.6458 mL 18.2289 mL 36.4578 mL 91.1444 mL
5 mM 0.7292 mL 3.6458 mL 7.2916 mL 18.2289 mL
10 mM 0.3646 mL 1.8229 mL 3.6458 mL 9.1144 mL
15 mM 0.2431 mL 1.2153 mL 2.4305 mL 6.0763 mL
20 mM 0.1823 mL 0.9114 mL 1.8229 mL 4.5572 mL
25 mM 0.1458 mL 0.7292 mL 1.4583 mL 3.6458 mL
30 mM 0.1215 mL 0.6076 mL 1.2153 mL 3.0381 mL
40 mM 0.0911 mL 0.4557 mL 0.9114 mL 2.2786 mL
50 mM 0.0729 mL 0.3646 mL 0.7292 mL 1.8229 mL
60 mM 0.0608 mL 0.3038 mL 0.6076 mL 1.5191 mL
80 mM 0.0456 mL 0.2279 mL 0.4557 mL 1.1393 mL
100 mM 0.0365 mL 0.1823 mL 0.3646 mL 0.9114 mL
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5-Methyl-2-thiouridine Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

5-Methyl-2-thiouridine32738-09-32-Thio-5-methyluridineNucleoside Antimetabolite/Analogindolent lymphoid malignanciesantitumorInhibitorinhibitorinhibit

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