2. Apoptosis Anti-infection Metabolic Enzyme/Protease
  3. Apoptosis Parasite Endogenous Metabolite
  4. 5'-Methylthioadenosine-d3

5'-Methylthioadenosine-d3  (Synonyms: 5'-(Methylthio)-5'-deoxyadenosine-d3; 5'-Deoxy-5'-(methylthio)adenosine-d3; 5'-S-Methyl-5'-thioadenosine-d3)

Cat. No.: HY-16938S1 Purity: 99.81%
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5'-Methylthioadenosine-d3 is the deuterium labeled 5'-Methylthioadenosine[1]. 5'-Methylthioadenosine (5'-(Methylthio)-5'-deoxyadenosine) is a nucleoside generated from S-adenosylmethionine (SAM) during polyamine synthesis. 5'-Methylthioadenosine suppresses tumors by inhibiting tumor cell proliferation, invasion, and the induction of apoptosis while controlling the inflammatory micro-environments of tumor tissue. 5'-Methylthioadenosine and its associated materials have striking regulatory effects on tumorigenesis[2][3][4].

For research use only. We do not sell to patients.

5'-Methylthioadenosine-d<sub>3</sub> Chemical Structure

5'-Methylthioadenosine-d3 Chemical Structure

CAS No. : 174838-38-1

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Based on 1 publication(s) in Google Scholar

Other Forms of 5'-Methylthioadenosine-d3:

5'-Methylthioadenosine-d3 Related Antibodies

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Description

5'-Methylthioadenosine-d3 is the deuterium labeled 5'-Methylthioadenosine[1]. 5'-Methylthioadenosine (5'-(Methylthio)-5'-deoxyadenosine) is a nucleoside generated from S-adenosylmethionine (SAM) during polyamine synthesis. 5'-Methylthioadenosine suppresses tumors by inhibiting tumor cell proliferation, invasion, and the induction of apoptosis while controlling the inflammatory micro-environments of tumor tissue. 5'-Methylthioadenosine and its associated materials have striking regulatory effects on tumorigenesis[2][3][4].

In Vitro

Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

5'-Methylthioadenosine-d3 Related Antibodies
Molecular Weight

300.35

Formula

C11H12D3N5O3S
CAS No.
Unlabeled CAS

2457-80-9
Appearance

Solid

Color

White to off-white

SMILES

NC1=C2N([C@]3([H])O[C@@H]([C@H]([C@H]3O)O)CSC([2H])([2H])[2H])C=NC2=NC=N1
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 50 mg/mL (166.47 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

DMSO : 50 mg/mL (166.47 mM; Need ultrasonic and warming; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

DMF : 2.5 mg/mL (8.32 mM; Need ultrasonic and warming)

DMF : 2.5 mg/mL (8.32 mM; Need ultrasonic)

H2O : 1 mg/mL (3.33 mM; Need ultrasonic)

H2O : 1 mg/mL (3.33 mM; Need ultrasonic)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 3.3294 mL 16.6472 mL 33.2945 mL
5 mM 0.6659 mL 3.3294 mL 6.6589 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
×
Volume
×
Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

×
Volume (start)

V1

=
Concentration (final)

C2

×
Volume (final)

V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

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(per animal)

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Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
H2O / H2O / DMF / DMF / DMSO / DMSO 1 mM 3.3294 mL 16.6472 mL 33.2945 mL 83.2362 mL
DMF / DMF / DMSO / DMSO 5 mM 0.6659 mL 3.3294 mL 6.6589 mL 16.6472 mL
DMSO / DMSO 10 mM 0.3329 mL 1.6647 mL 3.3294 mL 8.3236 mL
15 mM 0.2220 mL 1.1098 mL 2.2196 mL 5.5491 mL
20 mM 0.1665 mL 0.8324 mL 1.6647 mL 4.1618 mL
25 mM 0.1332 mL 0.6659 mL 1.3318 mL 3.3294 mL
30 mM 0.1110 mL 0.5549 mL 1.1098 mL 2.7745 mL
40 mM 0.0832 mL 0.4162 mL 0.8324 mL 2.0809 mL
50 mM 0.0666 mL 0.3329 mL 0.6659 mL 1.6647 mL
60 mM 0.0555 mL 0.2775 mL 0.5549 mL 1.3873 mL
80 mM 0.0416 mL 0.2081 mL 0.4162 mL 1.0405 mL
100 mM 0.0333 mL 0.1665 mL 0.3329 mL 0.8324 mL

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

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5'-Methylthioadenosine-d3 Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

5'-Methylthioadenosine-d3174838-38-15'-(Methylthio)-5'-deoxyadenosine-d35'-Deoxy-5'-(methylthio)adenosine-d35'-S-Methyl-5'-thioadenosine-d3ApoptosisParasiteEndogenous MetaboliteInhibitorinhibitorinhibit

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