2. Metabolic Enzyme/Protease Cell Cycle/DNA Damage
  3. Endogenous Metabolite DNA/RNA Synthesis
  4. Guanosine 5'-triphosphate trisodium salt

Guanosine 5'-triphosphate trisodium salt  (Synonyms: 5'-GTP trisodium salt)

Cat. No.: HY-12695 Purity: ≥95.0%
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Guanosine 5'-triphosphate (5'-GTP) trisodium salt is a G protein (G proteins) signaling activator and a high-energy precursor in the biosynthesis of nucleotide units in DNA and RNA. Guanosine 5'-triphosphate trisodium salt can promote myogenic cell differentiation by upregulating miRNA (miR133a, miR133b) and myogenic regulatory factor expression, and by inducing human myogenic precursor cells to release exosomes containing guanosine molecules. Guanosine-5'-triphosphate disodium salt holds promise for research in biosynthesis and skeletal muscle regeneration.

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Guanosine 5'-triphosphate trisodium salt Chemical Structure

Guanosine 5'-triphosphate trisodium salt Chemical Structure

CAS No. : 36051-31-7

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Based on 6 publication(s) in Google Scholar

Other Forms of Guanosine 5'-triphosphate trisodium salt:

Guanosine 5'-triphosphate trisodium salt Related Antibodies

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Description

Guanosine 5'-triphosphate (5'-GTP) trisodium salt is a G protein (G proteins) signaling activator and a high-energy precursor in the biosynthesis of nucleotide units in DNA and RNA. Guanosine 5'-triphosphate trisodium salt can promote myogenic cell differentiation by upregulating miRNA (miR133a, miR133b) and myogenic regulatory factor expression, and by inducing human myogenic precursor cells to release exosomes containing guanosine molecules. Guanosine-5'-triphosphate disodium salt holds promise for research in biosynthesis and skeletal muscle regeneration[1][2].

IC50 & Target

Human Endogenous Metabolite

 

In Vitro

Guanosine-5'-triphosphate disodium salt (500 μM, 24 h) significantly upregulates the expression of miR133a, miR133b, and the myogenic regulatory factor Myogenin in differentiated human myogenic precursor cells (MPCs)[2].
Guanosine-5'-triphosphate disodium salt (500 μM, 24 h) can induce the release of exosomes from human myogenic precursor cells[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Guanosine 5'-triphosphate trisodium salt Related Antibodies

RT-PCR[2]

Cell Line: Human myogenic precursor cells (MPCs)
Concentration: 500 μM
Incubation Time: 24 h
Result: Significantly upregulated Myogenin gene expression.
Molecular Weight

589.13

Formula

C10H13N5Na3O14P3
CAS No.
Appearance

Solid

Color

White to off-white

SMILES

O=P(OP(OP(O)(OC[C@@H]1[C@@H](O)[C@@H](O)[C@H](N2C=NC3=C2NC(N)=NC3=O)O1)=O)([O])=O)(O[Na])O[Na].[Na]
Structure Classification
Initial Source
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

-20°C, stored under nitrogen, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (stored under nitrogen, away from moisture)

Solvent & Solubility
In Vitro: 

H2O : 125 mg/mL (212.18 mM; Need ultrasonic)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 1.6974 mL 8.4871 mL 16.9742 mL
5 mM 0.3395 mL 1.6974 mL 3.3948 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (stored under nitrogen, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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This equation is commonly abbreviated as: C1V1 = C2V2

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In Vivo Dissolution Calculator
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Calculation results:
Working solution concentration: mg/mL
This product has good water solubility, please refer to the measured solubility data in water/PBS/Saline for details.
The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only.If necessary, please contact MedChemExpress (MCE).
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (stored under nitrogen, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
H2O 1 mM 1.6974 mL 8.4871 mL 16.9742 mL 42.4355 mL
5 mM 0.3395 mL 1.6974 mL 3.3948 mL 8.4871 mL
10 mM 0.1697 mL 0.8487 mL 1.6974 mL 4.2435 mL
15 mM 0.1132 mL 0.5658 mL 1.1316 mL 2.8290 mL
20 mM 0.0849 mL 0.4244 mL 0.8487 mL 2.1218 mL
25 mM 0.0679 mL 0.3395 mL 0.6790 mL 1.6974 mL
30 mM 0.0566 mL 0.2829 mL 0.5658 mL 1.4145 mL
40 mM 0.0424 mL 0.2122 mL 0.4244 mL 1.0609 mL
50 mM 0.0339 mL 0.1697 mL 0.3395 mL 0.8487 mL
60 mM 0.0283 mL 0.1415 mL 0.2829 mL 0.7073 mL
80 mM 0.0212 mL 0.1061 mL 0.2122 mL 0.5304 mL
100 mM 0.0170 mL 0.0849 mL 0.1697 mL 0.4244 mL

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

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Guanosine 5'-triphosphate trisodium salt Related Classifications

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  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Guanosine 5'-triphosphate trisodium36051-31-75'-GTP trisodiumEndogenous MetaboliteDNA/RNA SynthesisHuman myogenic precursor cells (MPCs)skeletal muscle regenerationInhibitorinhibitorinhibit

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