2. Metabolic Enzyme/Protease
  3. Liposome
  4. 5A2-SC8

5A2-SC8 is an ionizable amino lipid in lipid nanoparticles (LNPs) that shows high delivery potential and low in vivo toxicity, enabling efficient delivery of small RNAs such as siRNA and miRNA into tumor cells. 5A2-SC8 LNPs can confer a unique delivery fate of RNA within the liver, thereby changing the therapeutic outcomes in cancer models.

For research use only. We do not sell to patients.

5A2-SC8 Chemical Structure

5A2-SC8 Chemical Structure

CAS No. : 1857341-90-2

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1 mg USD 718 In-stock
5 mg USD 1580 In-stock
10 mg USD 2520 In-stock
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Customer Review

Based on 1 publication(s) in Google Scholar

5A2-SC8 Related Antibodies

Top Publications Citing Use of Products

1 Publications Citing Use of MCE 5A2-SC8

  • Biological Activity

  • Purity & Documentation

  • References

  • Customer Review

Description

5A2-SC8 is an ionizable amino lipid in lipid nanoparticles (LNPs) that shows high delivery potential and low in vivo toxicity, enabling efficient delivery of small RNAs such as siRNA and miRNA into tumor cells. 5A2-SC8 LNPs can confer a unique delivery fate of RNA within the liver, thereby changing the therapeutic outcomes in cancer models[1][2][3].

In Vitro

The ApoE protein corona adsorbs on the surface of 5A2-SC8 LNPs binds to LDL-R on the surface of hepatocytes and undergoes receptor-mediated endocytosis, and is taken up by hepatocytes[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

5A2-SC8 Related Antibodies
In Vivo

5A2-SC8 (75 mg/kg; i.v.; single-dose) is well tolerated and does not affect survival in mice with chronic aggressive hepatocellular carcinoma[1].
5A2-SC8 (0.5 mg/kg; i.v.; single-dose) can pass the first barrier of Kupffer cells in the liver and be internalized into hepatocytes in the presence of siFVII labeled with Cy5.5 dye[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Molecular Weight

1841.72

Formula

C93H173N5O20S5
CAS No.
Appearance

Oil

Color

Colorless to light yellow

SMILES

O=C(CCN(CCNCCN(CCC(OCCOC(C(CSCCCCCCCC)C)=O)=O)CCC(OCCOC(C(CSCCCCCCCC)C)=O)=O)CCNCCN(CCC(OCCOC(C(CSCCCCCCCC)C)=O)=O)CCC(OCCOC(C(CSCCCCCCCC)C)=O)=O)OCCOC(C(CSCCCCCCCC)C)=O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

-20°C, protect from light, stored under nitrogen

*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen)

Solvent & Solubility
In Vitro: 

DMSO : 100 mg/mL (54.30 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 0.5430 mL 2.7149 mL 5.4297 mL
5 mM 0.1086 mL 0.5430 mL 1.0859 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
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Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

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C2

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V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

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g

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(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation

Purity: 99.19%

COA (243 KB) HNMR (335 KB) RP-HPLC (253 KB) LCMS (220 KB)

Handling Instructions (2659 KB)
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 0.5430 mL 2.7149 mL 5.4297 mL 13.5743 mL
5 mM 0.1086 mL 0.5430 mL 1.0859 mL 2.7149 mL
10 mM 0.0543 mL 0.2715 mL 0.5430 mL 1.3574 mL
15 mM 0.0362 mL 0.1810 mL 0.3620 mL 0.9050 mL
20 mM 0.0271 mL 0.1357 mL 0.2715 mL 0.6787 mL
25 mM 0.0217 mL 0.1086 mL 0.2172 mL 0.5430 mL
30 mM 0.0181 mL 0.0905 mL 0.1810 mL 0.4525 mL
40 mM 0.0136 mL 0.0679 mL 0.1357 mL 0.3394 mL
50 mM 0.0109 mL 0.0543 mL 0.1086 mL 0.2715 mL
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5A2-SC8 Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

5A2-SC81857341-90-2LiposomeInhibitorinhibitorinhibit

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