5α-Cholestane-d₆

Name: 5α-Cholestane-d 6
Brand: MedChemExpress
SKU: HY-133970S
Rating: 4.5 (1 reviews)

Cat. No.: HY-133970S Purity: ≥99.0%: FAQs
Data Sheet SDS COA Handling Instructions

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5α-Cholestane-d₆ is the deuterium labeled 5α-Cholestane[1].

For research use only. We do not sell to patients.

5α-Cholestane-d<sub>6</sub> Chemical Structure

5α-Cholestane-d₆ Chemical Structure

CAS No. : 358731-18-7

Size	Price	Stock	Quantity
1 mg	USD 90	In-stock	Estimated Time of Arrival: December 31
5 mg	USD 300	In-stock	Estimated Time of Arrival: December 31
10 mg	USD 480	In-stock	Estimated Time of Arrival: December 31
50 mg		Get quote
100 mg		Get quote

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Based on 1 publication(s) in Google Scholar

Other Forms of 5α-Cholestane-d₆:

5α-Cholestane Get quote

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Biological Activity
Purity & Documentation
References
Customer Review

Description

5α-Cholestane-d₆ is the deuterium labeled 5α-Cholestane[1].

In Vitro

Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

378.71

Formula

C₂₇H₄₂D₆

CAS No.

358731-18-7

Unlabeled CAS

481-21-0

Appearance

Solid

Color

White to off-white

SMILES

C[C@@]12[C@](CC[C@]2([H])[C@H](C)CCCC(C)C)([H])[C@@]3([H])[C@@](CC1)([H])[C@@]4([C@@](C([2H])([2H])C([2H])([2H])C([2H])([2H])C4)([H])CC3)C

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Powder	-20°C	3 years
	4°C	2 years
In solvent	-80°C	6 months
	-20°C	1 month

Solvent & Solubility

In Vitro:

Ethanol : ≥ 20 mg/mL (52.81 mM)

DMF : ≥ 1 mg/mL (2.64 mM)

Ethanol:PBS (pH 7.2)(1:2) : ≥ 0.3 mg/mL (0.79 mM)

DMSO : ≥ 0.1 mg/mL (0.26 mM; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

*"≥" means soluble, but saturation unknown.

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	2.6405 mL	13.2027 mL	26.4054 mL
5 mM	0.5281 mL	2.6405 mL	5.2811 mL
10 mM	0.2641 mL	1.3203 mL	2.6405 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Concentration _(start)

Volume _(start)

Concentration _(final)

Volume _(final)

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Calculation results:

Working solution concentration: mg/mL

Purity & Documentation

Purity: ≥99.0%

Select Batch:

Data Sheet (272 KB) SDS (252 KB)

COA (250 KB)

Handling Instructions (2659 KB)

References

[1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53(2):211-216. [Content Brief]

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

DMF / DMF / Ethanol / Ethanol	1 mM	2.6405 mL	13.2027 mL	26.4054 mL	66.0136 mL
Ethanol / Ethanol	5 mM	0.5281 mL	2.6405 mL	5.2811 mL	13.2027 mL
	10 mM	0.2641 mL	1.3203 mL	2.6405 mL	6.6014 mL
	15 mM	0.1760 mL	0.8802 mL	1.7604 mL	4.4009 mL
	20 mM	0.1320 mL	0.6601 mL	1.3203 mL	3.3007 mL
	25 mM	0.1056 mL	0.5281 mL	1.0562 mL	2.6405 mL
	30 mM	0.0880 mL	0.4401 mL	0.8802 mL	2.2005 mL
	40 mM	0.0660 mL	0.3301 mL	0.6601 mL	1.6503 mL
	50 mM	0.0528 mL	0.2641 mL	0.5281 mL	1.3203 mL