2. Metabolic Enzyme/Protease
  3. Phosphatase
  4. 6,7-Dichloroquinoline-5,8-dione

6,7-Dichloroquinoline-5,8-dione (compound DA3002) is a potent CDC25B2 inhibitor with an IC50 value of 4.6 µM. 6,7-Dichloroquinoline-5,8-dione has the potential for the research of cancer.

For research use only. We do not sell to patients.

6,7-Dichloroquinoline-5,8-dione Chemical Structure

6,7-Dichloroquinoline-5,8-dione Chemical Structure

CAS No. : 6541-19-1

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6,7-Dichloroquinoline-5,8-dione Related Antibodies

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Description

6,7-Dichloroquinoline-5,8-dione (compound DA3002) is a potent CDC25B2 inhibitor with an IC50 value of 4.6 µM. 6,7-Dichloroquinoline-5,8-dione has the potential for the research of cancer[1].

IC50 & Target

IC50: 4.6 µM (CDC25B2)[1]
Cellular Effect
Cell Line Type Value Description References
C32 IC50
22.72 μM
Compound: 1
Cytotoxicity against human C32 cells harboring low levels of NQO1 after 72 hrs by WST1 assay
Cytotoxicity against human C32 cells harboring low levels of NQO1 after 72 hrs by WST1 assay
[PMID: 28006669]
CEM-SS CC50
1 μM
Compound: 81047
Cytotoxicity in human CEM-SS cells assessed as reduction in cell viability after 48 hrs by MTT assay
Cytotoxicity in human CEM-SS cells assessed as reduction in cell viability after 48 hrs by MTT assay
[PMID: 27663546]
HEK-293T CC50
17 μM
Compound: 81047
Cytotoxicity in HEK293T cells assessed as reduction in cell viability after 48 hrs by MTT assay
Cytotoxicity in HEK293T cells assessed as reduction in cell viability after 48 hrs by MTT assay
[PMID: 27663546]
HFF-1 IC50
15.66 μM
Compound: 1
Cytotoxicity against HFF1 after 72 hrs by WST1 assay
Cytotoxicity against HFF1 after 72 hrs by WST1 assay
[PMID: 28006669]
HL-60 IC50
31.8 μM
Compound: 7a
Antiproliferative activity against human HL60 cells after 48 hrs by MTT assay
Antiproliferative activity against human HL60 cells after 48 hrs by MTT assay
[PMID: 20363637]
MCF7 IC50
22.5 μM
Compound: 1
Cytotoxicity against human MCF7 cells harboring high levels of NQO1 after 72 hrs by WST1 assay
Cytotoxicity against human MCF7 cells harboring high levels of NQO1 after 72 hrs by WST1 assay
[PMID: 28006669]
MDA-MB-231 IC50
24.96 μM
Compound: 1
Cytotoxicity against human MDA-MB-231 cells harboring undetectable levels of NQO1 after 72 hrs by WST1 assay
Cytotoxicity against human MDA-MB-231 cells harboring undetectable levels of NQO1 after 72 hrs by WST1 assay
[PMID: 28006669]
MT4 CC50
2 μM
Compound: 81047
Cytotoxicity in human MT4 cells assessed as reduction in cell viability after 48 hrs by MTT assay
Cytotoxicity in human MT4 cells assessed as reduction in cell viability after 48 hrs by MTT assay
[PMID: 27663546]
Neutrophil IC50
1.3 μM
Compound: 7a
Antiinflammatory activity in human neutrophils assessed as inhibition of PMA-induced superoxide production after 20 mins by WST1 assay
Antiinflammatory activity in human neutrophils assessed as inhibition of PMA-induced superoxide production after 20 mins by WST1 assay
[PMID: 20363637]
SNB-19 IC50
26.1 μM
Compound: 1
Cytotoxicity against human SNB19 cells harboring undetectable levels of NQO1 after 72 hrs by WST1 assay
Cytotoxicity against human SNB19 cells harboring undetectable levels of NQO1 after 72 hrs by WST1 assay
[PMID: 28006669]
T-cell IC50
32.9 μM
Compound: 7a
Antiproliferative activity against human T cells after 48 hrs by MTT assay
Antiproliferative activity against human T cells after 48 hrs by MTT assay
[PMID: 20363637]
Molecular Weight

228.03

Formula

C9H3Cl2NO2
CAS No.
SMILES

C1=CN=C2C(=C1)C(=O)C(=C(C2=O)Cl)Cl
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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6,7-Dichloroquinoline-5,8-dione Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

6,7-Dichloroquinoline-5,8-dione6541-19-1Phosphatasedual specificity protein phosphatase Cdc25cancerInhibitorinhibitorinhibit

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